An observational study in Aortic Valve Stenosis, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2016-01-25.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
Aortic valve stenosis (AVS) is the most frequent valvular disease. The severity of the obstruction of the left ventricle (LV) is essentially analyzed today by echocardiography Doppler, which assesses two key markers that are aortic valve pressure gradient and the aortic valve area. however these marker are a poor reflect of the clinical severity of AVS. The aim of the study is to validate new markers assessing cardiac fibrosis that might best or complementary markers.
To validate new markers assessing cardiac fibrosis three groups of subjects were studied in controls subjects and patients with AVS in order to :
1,007 studies on the registry are indexed under Aortic Valve Stenosis; 284 are open to participants now.
This study's enrollment of 70 is below the median of 200 across 431 observational studies indexed under Aortic Valve Stenosis.
Browse Aortic Valve Stenosis studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,578 studies on the registry; 1,030 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Valvular Aortic Stenosis with or without surgery (symptomatic patients) or controls
PATIENTS :
Inclusion Criteria:
Exclusion Criteria:
CONTROLS (healthy volunteers)
Inclusion criteria:
Criteria for non-inclusion
Patients with symptomatic AVS had indication for surgery. They were proposed to have per procedure cardiac biopsy. They were followed when possible one year after surgery.
Procedure: Valvular aortic stenosis surgery
These patients with asymptomatic AVS had no indication for surgery. They were followed when possible one year after inclusion.
Patients without history of cardiac infarction, primary or secondary myocardiopathy or of radiotherapy or chemotherapy.
Dilatation of Valvular aortic stenosis
prevalence of myocardial fibrosis in MRI in patients with AVS
Indices of myocardial fibrosis will been analysed as combined criteria to analyse myocardial fibrosis
Time frame: At one year
comparison of these markers with myocardial histology
Fibrosis estimated by MRI will be compared to fibrosis on myocardial biopsy symptomatic patients with surgery only)
Time frame: At inclusion and at one year
Correlation with Doppler Echocardiography Assessment, and wall stress estimate by using both cardiac MR and carotid artery pressure (applanation tonometry)
Correlation of MRI with known markers of ventricular hypertrophy
Time frame: At inclusion and at one year
The record gives a start of Dec 2012, a primary completion of Nov 2015 and a completion of Nov 2015. It does not say whether these dates are actual or estimated.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.
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