An observational study in Community-acquired Pneumonia, sponsored by Hôpital Louis Mourier. Completed at 4 sites in France. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2016-02-26.
Sponsored by Hôpital Louis Mourier · Observational
To investigate exposure to nonsteroidal antiinflammatory drugs (NSAIDs) during outpatient management at the early stage of community-acquired pneumonia (CAP) requiring hospital consultation. Non-interventional observational study.
Recent data suggests that such exposure to NSAIDs is associated with delay in CAP diagnosis and antibiotic prescription that influence CAP presention and outcome. The investigators' working hypothesis is that NSAIDs use may mask initial symptoms and delay antimicrobial therapy, thus predisposing to worse outcomes. All patients presenting at one of the three following locations (emergency department, ICU or pneumology ward) with a suspicion of community-acquired pneumonia will be screened for eligibility. Exposure or not to NSAIDs will be investigated. Clinical, biological and radioloigcal features and outcome of CAP will be compared with respect to NSAIDs exposure.
90 studies on the registry are indexed under Community-Acquired Pneumonia; 53 are open to participants now.
This study's enrollment of 181 is below the median of 528 across 29 observational studies indexed under Community-Acquired Pneumonia.
Browse Community-Acquired Pneumonia studies →Hôpital Louis Mourier is the lead sponsor of 11 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
all adult patient presenting either to the emergency department or admitted directly to the ICU or the pneumology ward with a suspicion of CAP will be screened
Inclusion Criteria: at least two among the following signs
and new infiltrate on the chest x-ray
Exclusion Criteria:
binary composite primary endpoint
presence or absence of one or more of the following : occurrence of at least one pneumonia-related complication; need for ICU admission; prolonged length of hospital stay. pneumonia-related complications include: worsening of hypoxemia; need for mechanical ventilation; occurrence or increase of pleural effusion; empyema; occurrence of septic shock;
Time frame: 28 days
pneumonia severity index
the pneumonia severity index calculated at inclusion will be compared in exposed and non-exposed to NSAID patients
Time frame: 2 days
CURB score at inclusion
the CURB score (confusion, blood urea nitrogen, respiratory rate and systolic blood pressure) at inclusion will be compared in exposed and non-exposed to NSAID patients
Time frame: 2 days
duration of antimicrobial therapy
Time frame: 28 days
occurence of a nosocomial infection
occurrence of nosocomial infections (including nosocomial pneumonia, catheter-related blood stream infection, and urinary tract nosocomial infection) will be compared in exposed and non-exposed to NSAID patients
Time frame: 28 days
28-day mortality
Time frame: 28 days
chest pain
presence or absence of chest pain at inclusion will compared between exposed and non-exposed to NSAID patients
Time frame: 2 days
This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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Community-Acquired Pneumonia →
Hôpital Louis Mourier