An interventional study of Manuka Honey in Surgical Extraction of Impacted Third Molars, sponsored by Damascus University. Completed at 1 site in Syrian Arab Republic. Open to participants aged 20 Years to 37 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-12-07.
Sponsored by Damascus University · Not applicable, Interventional, and Treatment
Since there is an evidence that Manuka honey is an antibacterial agent, the present study aims to confirm this characteristic and assess its effect in improving healing and reducing postsurgical symptoms, if topically applied after the surgical removal of impacted mandibular third molars
Sufficient evidence exists recommending the use of honey in the management of acute wounds and burns. Studies revealed that the healing effect of honey could be classified by its antibacterial, antiviral, anti-inflammatory and antioxidant properties of its components. Manuka honey has been shown to inhibit a wide range of microorganisms, including multiresistant strains. This unique honey is derived from flowers of manuka tree (Leptospermum scoparium) in New Zealand. Dihydroxyacetone and methylglyoxal are unique and naturally occurring constituents of manuka honey that correlate with its antibacterial activity.
Since surgical extraction of impacted molars is one of the most common operations in the oral cavity and the postoperative symptoms disturbing the patient may reduce the quality of health service, this study aims to assess the healing potential of Manuka honey in reducing these symptoms by comparing the outcome of extraction of impacted lower molars with and without topical application of Manuka honey into the extraction socket.
195 studies on the registry are indexed under Tooth, Impacted; 20 are open to participants now.
This study's enrollment of 50 is close to the median of 53 across 164 interventional studies indexed under Tooth, Impacted.
Browse Tooth, Impacted studies →Damascus University is the lead sponsor of 206 studies on the registry; 10 are open to participants now.
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Exclusion Criteria:
Manuka Honey will be placed in the sockets of the extracted third molars in this group
Biological: Manuka Honey
No any special material will be placed in the sockets of the extracted third molars in this group
This material is going to be placed into the sockets of the extracted third molars in the experimental group
Levels of postoperative discomfort
Postoperative Symptom Severity (PoSSe) Scale will be used for this variable. The patient will be asked to fill in a questionnaire on the 7th day following surgery. This questionnaire is used to assess postoperative discomfort in patients who have third molars extracted. PoSSe Scale consists of 7 sub-scales that investigate the patient's ability to enjoy food; speak properly; perceive altered sensations, appearance, pain, and sickness; and interference with daily activities.
Time frame: 7 days after the surgical removal of third molars
Change of facial contours due to swelling
In order to assess facial swelling, the distances between the labial commissure and the tragus, and between the lateral canthus and the gonion will be measured. The change between 3 days and before surgery will give an idea about the amount of swelling that occurred following surgery. Between 3 days and 7 days will give an idea about the change that occurred in this period.
Time frame: Measurements will be taken before surgery, on the 3rd and on the 7th days after surgery.
Change of the masticatory muscles status
Mouth opening range will be assessed by measuring the distance between the upper and lower incisors using a vernier caliper when the patient is asked to open his/her mouth as much as possible. The presence of limited opening of the mouth is an indication of trismus.
Time frame: Measurements will be taken before surgery, on the 3rd and on the 7th days after surgery.
Pain and Change of pain
using a Visual Analog Scale of Faces (VASoF).
Time frame: This will be assessed on the 3rd and 7th day following surgery
The presence or absence of alveolar osteitis
The presence of a dry socket condition will be checked out at two time points.
Time frame: This will be assessed on the 3rd and 7th day following surgery
Time required to hemostasis
Time frame: This will be recorded by the patient in the immediate postsurgical phase (i.e. between 10 minutes up to 72 hours following surgery)
Bone density and quality
This will be assessed using Cone-beam computed tomography (CBCT) images. Hounsfield Units will be used to quantify bone density and quality.
Time frame: at six months following surgery
Change of bone healing status
This will be assessed using panoramic radiographs
Time frame: at 3 and six months following surgery
Plan to share: No
This study is completed, as verified in Dec 2016. You cannot join it, but the record below documents what was studied.
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Damascus University