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RecruitingNCT05439330Updated May 4, 2026

Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning

An interventional study of MRI of teeth and surrounding structures in TMJ, Apical Periodontitis and Periodontal Inflammation, sponsored by University of Aarhus. Recruiting at 1 site in Denmark. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-04.

Sponsored by University of Aarhus · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Started Sep 2022; still recruiting 4 years 2 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
470
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The aim of the present study is to show that the use of 0.55T MRI combined with a "dental" coil produces images of sufficient diagnostic value to assess areas of interest in dentistry, and to compare MR images to traditional, dental-oriented radiographic images for diagnostic purposes.

02

Conditions studied

  • TMJ
  • Apical Periodontitis
  • Periodontal Inflammation
  • Retained Tooth
  • MRI
03

In context

Periapical Periodontitis

280 studies on the registry are indexed under Periapical Periodontitis; 79 are open to participants now.

This study's planned enrollment of 470 is above the median of 60 across 245 interventional studies indexed under Periapical Periodontitis.

Browse Periapical Periodontitis studies →

Lead sponsor

University of Aarhus is the lead sponsor of 1,300 studies on the registry; 189 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • referred for CBCT imaging of at least one tooth for endodontic reasons
  • referred for intra-oral and/or panoramic imaging covering at least one molar tooth for periodontal reasons
  • referred for CBCT imaging of the TMJ (bilaterally)
  • referred for panoramic imaging of the third molar (retained/semi-retained, uni- or bilateral), prior to treatment planning
  • referred for CBCT imaging prior to implant treatment

Exclusion criteria

Exclusion Criteria:

  • younger than 18 years
  • unable to give consent
  • pregnant
  • pronounced claustrophobia
  • pacemakers or implanted defibrillators
  • metal shrapnel injuries of the eyes or MRI incompatible metallic inclusions or implants large tatoos
  • non-removable piercings
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
470 participants (estimated)

Study arms

  • Experimental
    Application of a dental-dedicated MRI

    MRI of conditions related to teeth and surrounding structures

    Device: MRI of teeth and surrounding structures

Interventions

  • DeviceMRI of teeth and surrounding structures

    included above

06

What researchers measure

Primary outcomes

  1. Application of a dental-dedicated MRI in the diagnosis of temporomandibular joint disorders, tissue alterations related to third molars, periapical and periodontal inflammatory diseases, and implant treatment planning

    Diagnosis of pathologies in the TMJ (e.g. disc displacement (anterior/posterior/lateral), inflammation (yes/no), bone changes (yes/no)), periodontal defects (e.g. bone defects (mm), inflammation (yes/no)), periapical pathology (e.g. inflammation (yes/no), apical periodontitis (yes/no)), bone measurements in edentulous areas, and third molars (e.g. relation to surrounding structures (over/same level/under nerve), resorption of neighboring teeth (yes/no)) seen on MRI compared to diagnosis obtained in radiographs. Observations seen on MRI will be compared to observations seen in radiographs.

    Time frame: 2½ years

07

Study locations

1 of 1 sites recruiting
  • IOOS
    Aarhus, 8000, Denmark
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05439330
Collaborators
Siemens Corporation, Corporate Technology, Dentsply Sirona Implants and Consumables
Responsible party
Jennifer Christensen (DDS, ph.d., University of Aarhus) — Principal investigator
First posted
Jun 30, 2022
Start date
Sep 1, 2022
Primary completion
Dec 31, 2026 (estimated)
Completion
Dec 31, 2026 (estimated)
Last update
May 4, 2026

Study contacts

Rubens Spin-Neto, ph.D
Contact
rsn@dent.au.dk
+4587159713
Rubens Spin-Neto, ph.D
study chair · University of Aarhus

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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