An interventional study of Scaling and root planing and Scaling and root planing with solution in Chronic Periodontitis, sponsored by University of Nebraska. Terminated at 1 site in United States. Open to participants aged 30 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-08-24.
Sponsored by University of Nebraska · Not applicable, Interventional, and Treatment
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD), reducing bleeding on probing (BOP), and gaining clinical attachment level (CAL). It also will assess whether chemical pocket disinfection with scaling and root planing will have an effect on biomarkers of inflammation.
The purpose of this study is to determine whether the adjunctive use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD), reducing bleeding on probing (BOP), and gaining clinical attachment level (CAL). It also will assess whether chemical pocket disinfection with scaling and root planing will have an effect on biomarkers of inflammation, as indicated by presence of pro- and anti-inflammatory cytokines, compared to scaling and root planing alone. The chemical pocket disinfection therapy consists of delivering a sodium hypochlorite solution followed by a neutralizing citric acid solution to the test site. Pro-inflammatory interleukin-1 beta and anti-inflammatory interleukin-1 receptor antagonist will be measured from the gingival crevicular fluid sampled from sites of interest.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 33 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →University of Nebraska is the lead sponsor of 473 studies on the registry; 66 are open to participants now.
Of its 75 completed or terminated interventional studies of FDA-regulated products, 46 (61%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Healthy sites with no inflammation; observational only
Inflamed pocket receiving mechanical instrumentation
Procedure: Scaling and root planing
Inflamed pocket receiving mechanical instrumentation with sodium hypochlorite solution
Procedure: Scaling and root planing with solution
Mechanical instrumentation
Mechanical instrumentation with sodium hypochlorite disinfective solution
Probing depths
Periodontal probing depth (PD)
Time frame: 3 months
Bleeding on probing
Incidence of bleeding during probing
Time frame: 3 months
Clinical attachment level
Clinical attachment level is calculated by adding gingival recession to probing depth; measures the connective tissue and epithelial attachment level relative to the cementoenamel junction
Time frame: 3 months
Inflammatory markers
Measure interleukin-1 beta and interleukin 1 receptor antagonist levels in gingival crevicular fluid from sites of interest
Time frame: 3 months
This study is terminated, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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University of Nebraska