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Status unknownNCT02098070Updated Aug 24, 2017

Knee Pain Phenotypes in the Community Study

An observational study in Knee Osteoarthritis, sponsored by University of Nottingham. Status unknown at 1 site in United Kingdom. Open to participants aged 40 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-08-24.

Sponsored by University of Nottingham · Observational

The sponsor has not verified this record recently (last verified Aug 2017), so the status shown — last known as Enrolling by invitation — may be out of date.
Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
40,000
Ages
40 Years and older
Sex
All
01

Study summary

The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over. It will also identify characteristics such as structural changes of osteoarthritis of the knee as well as physiological parameters and blood and urine biomarkers.

Read the detailed description

Number of participants:

Part I: questionnaire to 40,000 people aged 40 years and over (giving an expected 10,000 respondents) Part II: 400 participants.

02

Conditions studied

  • Knee Osteoarthritis

Keywords

  • Knee Pain
  • Community Study
  • Knee Osteoarthritis
  • Risk Factors
03

In context

Osteoarthritis

4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.

This study's planned enrollment of 40,000 is above the median of 100 across 791 observational studies indexed under Osteoarthritis.

Browse Osteoarthritis studies →

Lead sponsor

University of Nottingham is the lead sponsor of 455 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Community-derived sample

Inclusion criteria

  • Aged 40 years and over

Exclusion criteria

Exclusion criteria:

  • Inability to give informed consent
  • Terminal or mental illness
  • Pregnant women
05

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
40,000 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Knee Pain Population

    Participants who have responded to the questionnaire with self-reported pain.

  • Non-Knee Pain Population

    Participants who have responded to the questionnaire, no self-reported pain.

06

What researchers measure

Primary outcomes

  1. Knee Pain Phenotypes

    The prevalence of the different knee pain phenotypes, provided by specific pain questionnaires. This will include the Intermittent and Constant Osteoarthritis Pain Questionnaire (ICOAP), the Pain Catastrophizing Scale (PCS) and the PainDetect (for neuropathic pain).

    Time frame: up to 12 months

Secondary outcomes

  1. Other Risk Factors

    The risk factors for each knee pain phenotype, including age, gender, pain elsewhere, the Hospital Anxiety and Depression Scale (HADS), the pain catastrophizing scale and presence of osteoarthritis risk factors (BMI, finger ratio (2D4D), finger nodes, knee alignment) will be determined from the questionnaires.

    Time frame: up to 12 months

07

Study locations

1 site
  • Academic Rheumatology
    Nottingham, Nottinghamshire NG5 1PB, United Kingdom
08

References and documents

Publications

  • Swain S, Fernandes GS, Sarmanova A, Valdes AM, Walsh DA, Coupland C, Doherty M, Zhang W. Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort. Rheumatol Adv Pract. 2022 Jun 15;6(2):rkac049. doi: 10.1093/rap/rkac049. eCollection 2022. PubMed 35784017 ↗
  • Fernandes GS, Parekh SM, Moses J, Fuller CW, Scammell B, Batt ME, Zhang W, Doherty M. Depressive symptoms and the general health of retired professional footballers compared with the general population in the UK: a case-control study. BMJ Open. 2019 Sep 8;9(9):e030056. doi: 10.1136/bmjopen-2019-030056. PubMed 31501119 ↗
  • Fernandes GS, Valdes AM, Walsh DA, Zhang W, Doherty M. Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample. Arthritis Res Ther. 2018 Sep 27;20(1):215. doi: 10.1186/s13075-018-1717-6. PubMed 30261907 ↗
  • Fernandes GS, Sarmanova A, Warner S, Harvey H, Akin-Akinyosoye K, Richardson H, Frowd N, Marshall L, Stocks J, Hall M, Valdes AM, Walsh D, Zhang W, Doherty M. Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskelet Disord. 2017 Sep 21;18(1):404. doi: 10.1186/s12891-017-1761-4. PubMed 28934932 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 24, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02098070
Lead sponsor
University of Nottingham
Collaborators
Arthritis Research UK
Responsible party
Sponsor
First posted
Mar 27, 2014
Start date
Sep 2014
Primary completion
Sep 2018 (estimated)
Completion
Sep 2018 (estimated)
Last update
Aug 24, 2017

Study contacts

Michael Doherty, MD
principal investigator · University of Nottingham

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.

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