CompletedNCT02047695WOMANUpdated Apr 4, 2017

Women With Migraine With Aura Neuroimaging Study

An observational study in Migraine With Aura, sponsored by Odense University Hospital. Completed. Open to female participants aged 30 Years to 60 Years. Per ClinicalTrials.gov, last updated 2017-04-04.

Sponsored by Odense University Hospital · Observational

Study type: Observational
Model: Case-control
Time perspective: Cross-sectional
Enrollment: 345
Ages: 30 Years to 60 Years
Sex: Female

Study summary

The purpose of this study is to investigate whether a particular form of migraine, migraine with aura, is associated with structural changes in the brain

Conditions studied

Migraine With Aura

Browse trials for

Keywords

migraine with aura
migraine
case-control study
magnetic resonance imaging
brain diseases

In context

Migraine Disorders

1,528 studies on the registry are indexed under Migraine Disorders; 299 are open to participants now.

This study's enrollment of 345 is above the median of 130 across 299 observational studies indexed under Migraine Disorders.

Browse Migraine Disorders studies →

Lead sponsor

Odense University Hospital is the lead sponsor of 468 studies on the registry; 109 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 30 Years to 60 Years
Sexes eligible: Female
Accepts healthy volunteers: No
Sampling method: Non-probability sample

Study population

Selected from a population-based twin registry

Inclusion criteria

female
case (migraine with aura), co-twin to case, or control (migraine-free)
residency in Denmark
no severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders

Exclusion criteria

Exclusion Criteria:

male
residency outside Denmark
registered in Civil Registry as not to be contacted by researchers
severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders
mobile metal parts or other contraindication for MRI
weight of 130+ kilograms
pregnancy
subjects that wished not to be informed about abnormal findings on MRI
chronic tension-type headache, medication overuse headache, or cluster headache (diagnosed through physician interview)
frequent tension-type headache (control group only, self-reported or diagnosed through physician interview)

Study design

Observational model: Case-control
Time perspective: Cross-sectional
Enrollment: 345 participants (actual)
Patient registry: No

Groups and cohorts

Migraine with aura
Participants with migraine with aura (cases), their co-twins, and unrelated migraine-free twins (controls)

What researchers measure

Primary outcomes

Evidence of white matter hyperintensities or subclinical ischaemic stroke confirmed by MRI
Time frame: At time of MRI

Secondary outcomes

Evidence of other structural and functional changes in brain
Time frame: At time of MRI

Study locations

No study locations are listed for this record.

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Apr 4, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT02047695
Lead sponsor: Odense University Hospital
Collaborators: Glostrup University Hospital, Copenhagen, Copenhagen University Hospital, Hvidovre, University of Southern Denmark
Responsible party: David Gaist (professor, consultant, Odense University Hospital) — Principal investigator
First posted: Jan 28, 2014
Start date: Feb 2011
Primary completion: Apr 2015
Completion: Apr 2017
Last update: Apr 4, 2017

Study contacts

David Gaist, MD, PhD

principal investigator · Department of Neurology, Odense University Hospital

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2017. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Migraine Disorders→

Other studies from this sponsor

Odense University Hospital

Start the discussion