An interventional study of GPOU in Colorectal Cancer and Surgery, sponsored by Centre Hospitalier Universitaire de Nīmes. Recruiting at 4 sites in France. Open to participants aged 70 Years and older. Per ClinicalTrials.gov, last updated 2025-12-10.
Sponsored by Centre Hospitalier Universitaire de Nīmes · Not applicable, Interventional, and Supportive care
Health establishments encourage the development of specific care pathways for the elderly by supporting Geriatric Peri-Operative Units (GPOU). Indeed, this shared care model has shown a clear reduction in mortality and the number of re-hospitalizations in patients 6 months after their care. The multidisciplinary approach of global management of the patient in the perioperative period aims to reduce surgical stress as well as the rapid restoration of previous physical and psychic abilities. Colorectal surgery, the main treatment for stage I to III colon cancer, is a morbid surgery. Despite numerous efficacy data on improved rehabilitation after colorectal surgery, care programs are not specific to the geriatric population and geriatric assessment criteria to describe the functional status of patients are not commonly used. The study investigators wish to evaluate the impact of GPOU treatment following colorectal surgery, on the evolution of several clinical parameters such as: functional status, morbidity mortality, quality of life, and lifestyle. The study investigators hypothesize that management in the GPOU for colorectal cancer surgery in patients aged 70 and over will improve functional status at 3 months, in comparison with traditional management. The proposed intervention should also lead to an improvement in patient satisfaction with care, complications and re-hospitalizations, nutritional status, lifestyle and patient survival.
5,599 studies on the registry are indexed under Colorectal Neoplasms; 1,459 are open to participants now.
This study's planned enrollment of 90 is above the median of 77 across 4,123 interventional studies indexed under Colorectal Neoplasms.
Browse Colorectal Neoplasms studies →Centre Hospitalier Universitaire de Nīmes is the lead sponsor of 587 studies on the registry; 96 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Classical management in the digestive surgery department
Treatment is carried out in Peri-Operative Geriatrics Unit to optimize specific geriatric care
Other: GPOU
Intervention upstream of the perioperative management according to the nutritional grade. Grade 4 Nutrition patients will be hospitalized earlier, i.e. 10 to 15 days before surgery for the start of artificial nutrition. A temporary return home can be organized with the supervision of a service provider until a second admission for surgical management. Grade 2 Nutrition patients will be called 24 to 48 hours before the surgical procedure. Anticipation of discharge at admittance Early mobilization Comorbidity management Prevention of iatrogenia Management of geriatric frailties Daily medical and paramedical assessment Detailed discharge report
Change in functional status after colorectal cancer surgery between groups
Instrumental Activities of Daily Living (IADL) score (score 0-8)
Time frame: Baseline and Month 3
Change in functional status between groups
Instrumental Activities of Daily Living (IADL) score (score 0-8)
Time frame: Baseline and Month 6
Change in basic functional status between groups
Katz index of independence in Activities of Daily Living scale (ADL) (score 0-6)
Time frame: Baseline, hospital discharge (an average of 10 days), Month 3, and Month 6
Change in patient motor ability between groups
Time Up and Go test (Score 0-3 for each item, time in seconds)
Time frame: Baseline, Month 3
Patient satisfaction with care between groups
EORTC SATisfaction with IN-PATient cancer care (IN-PATSAT) 32 questionnaire (Score 32-160)
Time frame: Hospital discharge (an average of 10 days)
Length of hospital stay between groups
Days
Time frame: Hospital discharge (an average of 10 days)
The number of medical complications during hospitalization between groups
Number of following events: diabetes decompensation, cardiorespiratory decompensation, pulmonary and urinary infections, acute renal failure, anemia. Aggravation of: confusion, pelvic exoneration disorders, fall, bedsores.
Time frame: Hospital discharge (an average of 10 days)
The distribution of surgical complications between groups
Gravity of surgical complications according to the Clavien Dindo classification
Time frame: Hospital discharge (an average of 10 days)
The distribution of surgical complications between groups
Gravity of surgical complications according to the Clavien Dindo classification
Time frame: Month 1
Destination of patients on discharge from hospital between groups
Classified as: home / nursing home or institutionalization / transfer to Aftercare and Rehabilitation / transfer to another service / none (death during hospitalization).
Time frame: Hospital discharge (an average of 10 days)
The change in the patient's weight between groups
Percent change in Kg
Time frame: Baseline and Month 3
Patient quality of life between groups
EORTC-QLQ-C30 questionnaire score (Score 0-100)
Time frame: Month 3
Patient quality of life between groups
EORTC-QLQ-C30 questionnaire score (Score 0-100)
Time frame: Month 6
Change in the patient's place of abode between groups
Rate (%) of patients living at home/in nursing home/residential home
Time frame: Month 1, Month 3 and Month 6
Overall survival between groups.
Percentage of immediate mortality (during the hospital stay)
Time frame: Month 1
Overall survival between groups.
Percentage of immediate mortality (during the hospital stay)
Time frame: Month 3
Overall survival between groups.
Percentage of immediate mortality (during the hospital stay)
Time frame: Month 6
The rate of early unscheduled re-hospitalizations or admissions to the emergency department between groups
Re-hospitalization in the month following discharge from hospital: yes/no.
Time frame: Month 1
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Centre Hospitalier Universitaire de Nīmes