An interventional study of Aripiprazole in Schizophrenia, sponsored by Beijing HuiLongGuan Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2013-12-17.
Sponsored by Beijing HuiLongGuan Hospital · Not applicable, Interventional, and Treatment
Hyperprolactinemia is a frequent consequence of treatment with typical antipsychotic agents and atypical antipsychotics such as risperidone. Recent studies have suggested that aripiprazole, a partial dopamine agonist, reduces the prolactin response to antipsychotics. Thus, we conducted this study to evaluate the dose effects of adjunctive treatment with aripiprazole on hyperprolactinemia in stable schizophrenic patients maintained with risperidone.
3,563 studies on the registry are indexed under Schizophrenia; 491 are open to participants now.
This study's planned enrollment of 120 is above the median of 71 across 2,944 interventional studies indexed under Schizophrenia.
Browse Schizophrenia studies →Beijing HuiLongGuan Hospital is the lead sponsor of 22 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
risperidone plus placebo
risperidone treatment plus aripiprazole 5mg/day
Drug: Aripiprazole
risperidone plus aripiprazole 10mg/day
Drug: Aripiprazole
risperidone plus aripiprazole 20mg/day
Drug: Aripiprazole
Prolactin level
Change from baseline in the levels of prolactin
Time frame: baseline, 2 weeks, 4 weeks, 8 weeks
PANSS (positive and negative syndrome scale) score
Change from baseline in PANSS score
Time frame: Baseline, 8 weeks
extrapyramidal symptoms
assess the extrapyramidal symptoms
Time frame: baseline, 4 weeks, 8 weeks
This study is status unknown, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Aripiprazole
Beijing HuiLongGuan Hospital