An interventional study of Natural Psychotherapy and waitlist control group in Obsessive-Compulsive Disorder, sponsored by Beijing HuiLongGuan Hospital. Completed at 2 sites in China. Open to participants aged 16 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-10.
Sponsored by Beijing HuiLongGuan Hospital · Not applicable, Interventional, and Treatment
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
Exclusion Criteria:
Intervention using natural psychotherapy for OCD patients for two to three hours once a week for eight weeks
Behavioral: Natural Psychotherapy
The waiting group will not undergo any intervention adjustments within the next two months and will not receive any other psychological interventions.
Behavioral: waitlist control group
Natural psychotherapy is based on "Morita therapy" and is a psychotherapy that fully reflects the characteristics of Chinese culture, taking into account the Chinese cultural background and actual clinical characteristics.
waitlist control group
Obsessive-compulsive symptoms
Using the score of Yale-Brown Obsessive-Compulsive Scale as the primary outcome, a decrease in score of ≥35% was considered a 'response to treatment', also referred to as a 'full response', and a decrease in score of ≥25% was considered a 'partial response'
Time frame: Baseline, week 4, week 8
Self-reported obsessive-compulsive symptoms
The reduction rate of the score of Obsessive-Compulsive Inventory-Revised (OCI-R), a self-rating scale of OCD symptoms severity, was employed as a secondary outcome
Time frame: Baseline, week 4, week 8
Cognitive inhibition
Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability.
Time frame: Baseline, week 8
Behavioral inhibition
Behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability.
Time frame: Baseline, week 8
ERP components associated with cognitive function
To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis
Time frame: Baseline, week 8
rest fMRI in Obsessive-compulsive patients
The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity：FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences.
Time frame: Baseline, week 8
Plan to share: No — Data with be available on request
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Obsessive-Compulsive Disorder→
Beijing HuiLongGuan Hospital