An interventional study of Dexmedetomidine in Sepsis and Agitation, sponsored by First Affiliated Hospital of Zhejiang University. Completed at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2022-03-22.
Sponsored by First Affiliated Hospital of Zhejiang University · Not applicable, Interventional, and Supportive care
Septic patients in Intensive Care Unit always need mechanical ventilation and conscious-sedation. But the recommended dose 0.2-0.7μg/kg/h could not run well because of wide range. The purpose of this study is to find the effective dose of dexmedetomidine adult septic patients of mechanical ventilation .
Inclusion Criteria:
Age: between 18 years mechanical ventilation RASS≥2 A diagnosis of sepsis within 48 hours
Exclusion Criteria:
Cardiac disease Cardiac rhythm abnormalities liver dysfunction coma severe hypotension muscle relaxant users
Primary Outcome Measures:
Dose of dexmedetomidine
Secondary Outcome Measures:
RASS score Requirement for rescue intervention, RASS will be recorded per hour.
1,946 studies on the registry are indexed under Sepsis; 471 are open to participants now.
This study's planned enrollment of 40 is below the median of 105 across 918 interventional studies indexed under Sepsis.
Browse Sepsis studies →First Affiliated Hospital of Zhejiang University is the lead sponsor of 260 studies on the registry; 141 are open to participants now.
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Exclusion Criteria:
Intervention Name: dexmedetomidine dosage form: intravenous injection dosage：0.2-0.7μg/kg/h frequency: 1 duration:12 hours
Drug: Dexmedetomidine
Septic patients are randomly received 1 of 6 doses( 0.2,0.3,0.4,0.5,0.6,0.7μg/kg/h) dexmedetomidine.
Also known as: precedex
Dose of dexmedetomidine
Time frame: 12 hours
RASS score Requirement for rescue intervention, RASS will be recorded per hour.
Time frame: 1 hour
This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Dexmedetomidine
First Affiliated Hospital of Zhejiang University →