An interventional study of Cognitive Remediation Therapy and Placebo comparator in Schizophrenia and Psychosis, sponsored by University of Dublin, Trinity College. Status unknown at 1 site in Ireland. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-12-05.
Sponsored by University of Dublin, Trinity College · Not applicable, Interventional, and Treatment
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with chronic schizophrenia or other psychoses.
Cognitive deficits are a problem for many people with schizophrenia. This study will use computerized cognitive remediation training (which the participant can carry out at home) over a period of a few months.
The aim of this project is to undertake a randomized placebo controlled trial of cognitive remediation therapy (CRT) that focuses on working memory training in a sample of community based patients with schizophrenia. Pre and Post neuropsychological assessment and Magnetic Resonance Imagery (MRI) will be used to determine the effects of CR training on
The cognitive remediation intervention is a computerised programme whose training level is dynamically varied to suit participants individual ability level. Motivation to learn and generalization to real world function are a particular focus of the intervention and are supported with ongoing therapist interaction in addition to personal training.
3,470 studies on the registry are indexed under Schizophrenia; 471 are open to participants now.
This study's planned enrollment of 80 is above the median of 70 across 2,871 interventional studies indexed under Schizophrenia.
Browse Schizophrenia studies →University of Dublin, Trinity College is the lead sponsor of 72 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will undertake approximately 30 minutes of computerized CRT training for 8 weeks, 5 days per week. They will meet a therapist once per week to discuss any difficulties, help motivation.
Other: Cognitive Remediation Therapy
Participants will meet therapist once per week but will not undertake the Computerized Cognitive remediation training.
Other: Placebo comparator
Computerised training undertaken for approximately 30 minutes per day, 5 days per week for 8 weeks
Also known as: CRT
Participant meets the therapist once per week but does not carry out the CRT intervention. (Participants are subsequently offered the chance to carry out the CRT intervention post study if they so wish).
Also known as: No intervention
Change from baseline neuropsychological performance
A battery of neuropsychological tests will be used at baseline and the same tests used directly after the intervention to measure changes in attention and memory. Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory.
Time frame: Directly following study treatment period
Change from baseline neuropsychological performance at 3 to 6 months post intervention
A battery of neuropsychological tests will be used at baseline and the same tests used at 3 months post intervention to measure changes in attention and memory. Tests include Wechsler Adult intelligence scale-III, Wechsler Memory Scale-III, Stroop test, Wisconsin card sorting task and measures of spatial working memory.
Time frame: 3 to 6 months post study treatment period
Changes from baseline in brain activation during working memory testing
Changes from baseline in brain activation during working memory testing will be measured using fMRI
Time frame: Directly post study treatment period
Change from baseline in grey matter volume
Changes in grey matter volume from baseline will be measured at 3 months post intervention using voxel based morphometry.
Time frame: Directly following study treatment period
Changes in social and occupational functioning
Social and occupational function will be measured at baseline and the same tests used directly following intervention. Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B)
Time frame: Directly following study treatment period
Change from baseline in social and occupational functioning 3 to 6 months post intervention
Social and occupational function will be measured at baseline and the same tests used directly following intervention. Standardised measures will be used including ILS (Independent Living Scales) and the UCSD performance skills assessment brief version(UPSA-B)
Time frame: 3 to 6 months post study treatment period
This study is status unknown, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
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University of Dublin, Trinity College