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CompletedNCT01898858H2PAPUpdated Oct 15, 2014

Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic

An observational study in Pulmonary Vascular Sensibility in Hypoxia, Hypercapnia and Hypoxia and Hypercapnia, sponsored by University Hospital, Strasbourg, France. Completed at 1 site in France. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-10-15.

Sponsored by University Hospital, Strasbourg, France · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
8
Ages
18 Years to 40 Years
Sex
Male
01

Study summary

The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during a short constant load exercise in 4 conditions :

  • normoxia
  • hypoxia
  • hypercapnia
  • association hypoxia and hypercapnia
02

Conditions studied

  • Pulmonary Vascular Sensibility in Hypoxia
  • Hypercapnia
  • Hypoxia and Hypercapnia
03

In context

Hypoxia

1,231 studies on the registry are indexed under Hypoxia; 241 are open to participants now.

This study's enrollment of 8 is below the median of 67 across 335 observational studies indexed under Hypoxia.

Browse Hypoxia studies →

Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 966 studies on the registry; 342 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Healthy volunteers

Inclusion criteria

  • healthy male
  • exercise capacity between 100 and 130 % of theorical values

Exclusion criteria

Exclusion criteria:

  • smoker
  • headache
  • impossibility to perform an exercise test
  • no tricuspid regurgitation on the echocardiography
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
8 participants (actual)
Patient registry
No

Groups and cohorts

  • HYPOXIA

    Device: Hypoxia inhalation (Altitrainer NP 190)

  • HYPERCAPNIA

    Device: Hypercapnia inhalation (Altitrainer NP 190)

  • HYPOXIA + HYPERCAPNIA

    Device: Hypoxia and hypercapnia (Altitrainer NP 190)

Interventions

  • DeviceHypercapnia inhalation (Altitrainer NP 190)

    Hypercapnia inhalation using an Altitrainer NP 190

  • DeviceHypoxia and hypercapnia (Altitrainer NP 190)

    Hypoxia and hypercapnia inhalation using an Altitrainer NP 190

  • DeviceHypoxia inhalation (Altitrainer NP 190)

    Hypoxia inhalation using an Altitrainer NP 190

06

What researchers measure

Primary outcomes

  1. Systolic Artery Pulmonary Pressure(sPAP) (echocardiography, Cardiac output (impedancemetry), Cardiorespiratory parameters

    At rest and during exercise for each condition

    Time frame: at the end of the 30th minutes constant load exercise

Secondary outcomes

  1. Dyspnea and muscle leg discomfort using a Borg Scale

    In each conditions at rest and during exercise

    Time frame: at the end of the 30th minutes constant load exercise

07

Study locations

1 site
  • Service de Physiologie et d'Explorations Fonctionnelles, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg
    Strasbourg, 67091, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 15, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01898858
Lead sponsor
University Hospital, Strasbourg, France
Responsible party
Sponsor
First posted
Jul 12, 2013
Start date
Sep 2013
Primary completion
Oct 2014
Completion
Oct 2014
Last update
Oct 15, 2014

Study contacts

PISTEA Cristina, MD
principal investigator · Hôpitaux Universitaires de Strasbourg

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2014. You cannot join it, but the record below documents what was studied.

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