An interventional study of Hypoxia and Placebo in Headache, Migraine and Aura, sponsored by Danish Headache Center. Completed at 1 site in Denmark. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-02-12.
Sponsored by Danish Headache Center · Not applicable, Interventional, and Basic science
In this study the investigators will investigate the following hypothesis
To investigate migraine with aura symptoms during and after hypoxia.
With magnetic resonance imaging the investigators will investigate changes in
And compare these changes with a aged match healthy control group.
1,528 studies on the registry are indexed under Migraine Disorders; 299 are open to participants now.
This study's enrollment of 34 is below the median of 80 across 1,175 interventional studies indexed under Migraine Disorders.
Browse Migraine Disorders studies →Danish Headache Center is the lead sponsor of 125 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Migraine with aura patients and Helthy volunteers as controls:
Exclusion Criteria:
Extra exclusion Criteria for healthy volunteers:
Inhalation of air with 8-12% oxygen content
Other: Hypoxia
Inhalation of atmospheric air, with oxygen content at 21%
Other: Placebo
Inhalation of hypoxic air (8-12% oxygen content)
Inhalation of atmospheric air
Headache and aura
Comparison between hypoxia and placebo (atmospheric air)
Time frame: 24 h
artery circumference
Hypoxia induced changes in intra- and extracranial circumference
Time frame: Baseline, 120 and 200 min
Cerebral blood flow
Hypoxia induced changes in cerebral blood flow
Time frame: Baseline, 120 and 200 min
BOLD response in visual cortex
Hypoxia induced changes in BOLD response
Time frame: Baseline, 170 min and 220 min
Brain metabolism
Hypoxia induced changes in brain metabolism
Time frame: Baseline, 180 min and 230 min post hypoxia
This study is completed, as verified in Feb 2015. You cannot join it, but the record below documents what was studied.
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Danish Headache Center