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Status unknownNCT01877798Updated Jun 14, 2013

Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy

An interventional study of volume resuscitation, vasoactive drug in Septic Shock, sponsored by Peking Union Medical College Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-06-14.

Sponsored by Peking Union Medical College Hospital · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Jun 2013), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
300
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Reducing tissue hypoxia is the ultimate goal of severe sepsis and septic shock therapy.Venoarterial PCO2 difference /arteriovenous O2 content difference ratio (△PCO2/Ca-vO2) is considered to be a good indicator of global anaerobic metabolism.The purpose of this study was to compare the efficacy of △PCO2/Ca-vO2 and central venous oxygen saturation (ScvO2) in the treatment of severe sepsis and septic shock.

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Conditions studied

  • Septic Shock

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03

In context

Shock, Septic

890 studies on the registry are indexed under Shock, Septic; 210 are open to participants now.

This study's planned enrollment of 300 is above the median of 78 across 547 interventional studies indexed under Shock, Septic.

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Lead sponsor

Peking Union Medical College Hospital is the lead sponsor of 1,148 studies on the registry; 474 are open to participants now.

Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

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Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

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Inclusion criteria

  • severe sepsis and septic shock patients

Exclusion criteria

Exclusion Criteria:

  • \<18 years old
  • pregnant and breast-feed woman
  • AMI
  • cerebral hemorrhage
  • contraindication for central venous catheter or arterial catheter;
  • brainstem death
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
300 participants (estimated)

Study arms

  • Experimental
    △PCO2/Ca-vO2

    △PCO2/Ca-vO2 directed group

    Procedure: volume resuscitation, vasoactive drug

  • Experimental
    ScvO2

    ScvO2 directed group

    Procedure: volume resuscitation, vasoactive drug

Interventions

  • Procedurevolume resuscitation, vasoactive drug
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What researchers measure

Primary outcomes

  1. mortality

    Time frame: 30 days

07

Study locations

1 site
  • Peking Union Medical College Hospital critical care medicine
    Beijing, China
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References and documents

Publications

  • Su L, Tang B, Liu Y, Zhou G, Guo Q, He W, Wang C, Zhuang H, Jiang L, Qin L, Deng Q, Shuai W, Zhang L, Wang X, Su J, Ma S, Liu D, Long Y. P(v-a)CO2/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: A prospective multicenter randomized controlled clinical study. J Crit Care. 2018 Dec;48:314-320. doi: 10.1016/j.jcrc.2018.09.009. Epub 2018 Sep 11. PubMed 30278407 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 14, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01877798
Lead sponsor
Peking Union Medical College Hospital
Responsible party
Sponsor
First posted
Jun 14, 2013
Start date
Jun 2013
Primary completion
Jun 2016 (estimated)
Last update
Jun 14, 2013

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2013. You cannot join it, but the record below documents what was studied.

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