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Enrolling by invitationNCT07891572Updated Oct 23, 2026

Oxaliplatin-Based Adjuvant Therapy for Gastrointestinal Neuroendocrine Carcinoma**

An observational study in Gastrointestinal Neuroendocrine Carcinoma, Adjuvant Treatment and Resection, sponsored by Peking Union Medical College Hospital. Enrolling by invitation at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-10-23.

Sponsored by Peking Union Medical College Hospital · Observational

Updated Oct 23, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
42
Ages
18 Years to 75 Years
Sex
All
01

Study summary

Patients with pathologically-confirmed gastrointestinal neuroendocrine carcinoma will be enrolled, to explore the efficacy and safety of oxaliplatin-based doublet chemotherapy in the adjuvant treatment of gastrointestinal neuroendocrine carcinoma. For patients after radical resection, adjuvant chemotherapy is recommended. XELOX, SOX or FOLFOX regimens can be selected based on the patient's physical status. Single-agent chemotherapy alone is not recommended.

02

Conditions studied

  • Gastrointestinal Neuroendocrine Carcinoma
  • Adjuvant Treatment
  • Resection
03

In context

Lead sponsor

Peking Union Medical College Hospital is the lead sponsor of 1,148 studies on the registry; 474 are open to participants now.

Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with pathologically-confirmed gastrointestinal neuroendocrine carcinoma will be enrolled

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Histopathologically-confirmed diagnosis of gastrointestinal neuroendocrine carcinoma
  • Patients with radical resection of tumour, unresectable locally-advanced disease or metastatic disease, regardless of tumour stage;
  • No restriction on gender, aged between 18 and 75 years old;
  • Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 1. Hematological, hepatic and renal function parameters meet the criteria for chemotherapy administration;
  • Expected survival time ≥ 3 months;
  • Agree to undergo examinations, treatment and follow-up in accordance with this study protocol; agree to provide clinicopathological and follow-up data required for the study; and consent to the use of study-related data for subsequent research;
  • Voluntarily participate in this clinical trial, understand the study procedures and be capable of signing the informed consent form.

Exclusion criteria

Exclusion Criteria:

  • Presence of another concurrent malignant tumour within 5 years prior to enrolment;
  • Received any anti-tumour therapy within six months before enrolment;
  • In the investigator's judgment, the patient has concomitant diseases (such as uncontrolled hypertension, severe diabetes, thyroid disorders, psychiatric diseases, etc.) or any other conditions that would seriously endanger patient safety or prevent completion of this study.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
42 participants (estimated)
Patient registry
No

Groups and cohorts

  • oxaliplatin-based doublet chemotherapy

    For patients after radical resection, adjuvant chemotherapy is recommended. XELOX, SOX or FOLFOX regimens can be selected based on the patient's physical status

06

What researchers measure

Primary outcomes

  1. DFS

    Disease-Free Survival

    Time frame: For post-operative patients, defined as the time from initiation of adjuvant therapy until the date of tumour recurrence, metastasis, or death from any cause, assessed up to 60 months.

Secondary outcomes

  1. OS

    Overall Survival

    Time frame: Defined as the time from initiation of adjuvant therapy or first-line treatment until the date of patient's death from any cause, assessed up to 60 months.

07

Study locations

1 site
  • Peking Union Medical College Hospital
    Beijing, Beijing Municipality 100730, China
08

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 23, 2026
Show all 1 update
  1. Oct 23, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT07891572
Responsible party
YueJuan Cheng (Professor, Peking Union Medical College Hospital) — Principal investigator
First posted
Oct 23, 2026
Start date
Sep 2026 (estimated)
Primary completion
Sep 2031 (estimated)
Completion
Sep 2036 (estimated)
Last update
Oct 23, 2026
View the source record on ClinicalTrials.gov ↗

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