CompletedNCT01865604Updated Mar 16, 2016

Impact of tDCS on Cerebral Autoregulation

An interventional study of Anodal tDCS and Cathodal tDCS in Cerebral Microangiopathy, CADASIL and Migraine With Aura, sponsored by Charite University, Berlin, Germany. Completed at 1 site in Germany. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-03-16.

Primary conditionCADASILRegistry: Cerebral Small Vessel DiseasesReclassifiedWhy we changed it

Registry

Cerebral Small Vessel Diseases — the first condition term the registry derived for this study.

ClinicalTrials.gg

CADASIL

Why

The study's listed conditions name CADASIL, a narrower term within Cerebral Small Vessel Diseases.

Confidence

High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →

Wrong?

Tell us the study's main condition →

Sponsored by Charite University, Berlin, Germany · Not applicable, Interventional, and Basic science

Phase: Not applicable
Study type: Interventional
Enrollment: 60
Allocation: Randomized
Ages: 18 Years to 80 Years
Sex: All

Study summary

The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.

Conditions studied

Cerebral Microangiopathy
CADASIL
Migraine With Aura
ICA Stenosis

Browse trials for

Cerebral Small Vessel Diseases 128Registry's first term
CADASIL 33Primary · reclassified
Migraine with Aura 114

In context

CADASIL Reclassified

33 studies on the registry are indexed under CADASIL; 18 are open to participants now.

This study's enrollment of 60 is close to the median of 60 across 10 interventional studies indexed under CADASIL.

Browse CADASIL studies →

Lead sponsor

Charite University, Berlin, Germany is the lead sponsor of 857 studies on the registry; 129 are open to participants now.

Browse Charite University, Berlin, Germany studies →

Compared within CADASIL, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Cerebral Small Vessel Diseases. The counts are of registry records indexed under each term, refreshed daily. How we classify →

Who can participate

Ages eligible: 18 Years to 80 Years
Sexes eligible: All
Accepts healthy volunteers: Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

severe cerebral Microangiopathy
NOTCH3 carrier
Migraine with aura (IHS Classification ICHD-II)
Stenosis >80%, ECST-Criteria

Exclusion criteria

Exclusion Criteria:

seizure disorder
history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity
dementia

(1+2) history of stroke in past 3 months (3) migraine prophylaxis (4) contralateral stenosis >50%,

Study design

Phase: Not applicable
Primary purpose: Basic science
Allocation: Randomized
Intervention model: Crossover assignment
Masking: Triple (Participant, Investigator, Outcomes assessor)
Enrollment: 60 participants (actual)

Study arms

Experimental
Anodal tDCS
anaodal transcranial direct current stimulation
Device: Anodal tDCS
Active comparator
Cathodal tDCS
cathodal transcranial direct current stimulation
Device: Cathodal tDCS
Sham comparator
Sham tDCS
no stimulation
Device: sham tDCS

Interventions

DeviceAnodal tDCS
DeviceCathodal tDCS
Devicesham tDCS

What researchers measure

Primary outcomes

Cerebral vasomotor reactivity assessed by transcranial Dopplersonography
comparing cerebral vasomotor reactivity at baseline and after anodal/cathodal/sham stimulation
Time frame: on 3 days within 12 weeks

Study locations

1 site

Department of Neurology, Charité Universitätsmedizin Berlin
Berlin, 10117, Germany

Timeline

Tracking since Sep 25, 2026

Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Apr 2012, a primary completion of Mar 2014 and a completion of Mar 2014. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered: Dec 18, 2012
First posted: May 31, 2013
Start: Apr 2012
Primary completionActual: Mar 2014
CompletionActual: Mar 2014
Last update: Mar 16, 2016

What these dates mean

Start.: When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.: When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.: When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.: Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.

No changes since tracking began. The registry record was last updated on Mar 16, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01865604
Lead sponsor: Charite University, Berlin, Germany
Responsible party: Agnes Flöel (Prof. Dr. med. Agnes Floeel, Charite University, Berlin, Germany) — Principal investigator
First posted: May 31, 2013
Start date: Apr 2012
Primary completion: Mar 2014
Completion: Mar 2014
Last update: Mar 16, 2016

Study contacts

Agnes Flöel, Prof. MD

principal investigator · Charite University, Berlin, Germany

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.

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Discussion

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