An observational study in Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction and Right Heart Failure, sponsored by University Hospital, Grenoble. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-11-08.
Sponsored by University Hospital, Grenoble · Observational
Acute respiratory distress syndrome (ARDS) and mechanical ventilation can lead to right ventricular dysfunction and ultimately right ventricular failure by increasing pulmonary vascular resistances and pressure load. This can be prevented by modifying ventilator settings, using vasopressors or inotropes or even by prone positionning.But to do so, right ventricular dysfonction has to be detected. Echocardiography has emerged as a first line tool to diagnose right heart failure. Recently, strain analysis showed promising results to detect early right ventricle abnormalities in other settings such as pulmonary hypertension or scleroderma. We therefore decided to determine whether 2D strain could help detect early right ventricular dysfunction in ARDS.
1,387 studies on the registry are indexed under Respiratory Distress Syndrome; 283 are open to participants now.
This study's enrollment of 47 is below the median of 100 across 475 observational studies indexed under Respiratory Distress Syndrome.
Browse Respiratory Distress Syndrome studies →University Hospital, Grenoble is the lead sponsor of 837 studies on the registry; 207 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients are recruited in our medical intensive care unit at Grenoble University Hospital.
ARDS group
Inclusion Criteria:
Exclusion Criteria:
ALI group:
Inclusion Criteria:
Exclusion Criteria:
Control Group:
Inclusion Criteria:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients under mechanical ventilation since less than 24 hours at inclusion and presenting acute respiratory distress syndrome criteria.
Patients under mechanical ventilation and presenting acute lung injury criteria.
Patients under mechanical ventilation for a non-respiratory cause
Right ventricle 2D strain
We will assess whether 2D strain can detect a right ventricular dysfunction as compared to standard echocardiographic parameters
Time frame: Duration of mechanical ventilation
Mean right ventricle strain under ventilated patients
We measure right ventricle strain (RV strain) in patients under mechanical ventilation for a non-respiratory cause. This allows us to determine the mean value of RV strain under ventilation when there is no respiratory failure.
Time frame: at inclusion
Reproducibility between transthoracic and transesophageal strain measures
In ARDS patients, we record a transthoracic and transesophageal echocardiography. We compare RV strain values obtained from transthoracic and transesophageal echocardiography.
Time frame: Time of mechanical ventilation
NT pro BNP and pre pro endothelin plasma level
These assays are made based on the hypothesis they could help discriminate between patients who will develop a right ventricular dysfunction from those who will not. A blood sample is withdrawn at the same time as echocardiography only in the ARDS group.
Time frame: At inclusion in ARDS patients
This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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