An interventional study of NEFA and Sucrose in Hypogeusia, sponsored by Purdue University. Completed at 1 site in United States. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-11-21.
Sponsored by Purdue University · Not applicable, Interventional, and Basic science
This study will examine whether or not short, daily exposures change a person's ability to detect free fatty acids in a solution by its taste. Repeated exposure should improve a person's ability to detect free fatty acids.
The possibility that humans can taste non-esterified fatty acids (NEFA) - so-called fat taste - is a relatively new area of research. Previous work suggests that subjects require an average of between two and three testing sessions of approximately an hour each before they can reliably detect NEFA, and the average number of visits to get the lowest threshold is six. Streamlining this process is of great interest to researchers who wish to test many people as quickly as possible. Other taste qualities, including umami and sweet, have shown improvement in detection sensitivity in subjects that have undergone ten second exposures to these taste qualities for 10 days upon subsequent re-testing. We seek to determine if the same improvements can be seen with fat taste.
Purdue University is the lead sponsor of 168 studies on the registry; 23 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants swish and spit 5 mL of an oleic acid solution everyday for 10 days.
Other: NEFA
Participants swish and spit 5 mL of sucrose solution everyday for 10 days.
Other: Sucrose
Also known as: Oleic acid
NEFA detection threshold
Time frame: 10 days
Hunger
Visual analog scale assessment of hunger level prior to testing
Time frame: 2 days
BMI
Time frame: 1 day
Taste descriptor
Description of NEFA taste by participant, e.g., sour, bitter, etc.
Time frame: 10 days
This study is completed, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Ageusia
Purdue University