A Phase 4 interventional study of Early-Dexamethasone and Late dexamethazone in Covid19 and Anosmia, sponsored by ClinAmygate. Recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-09-06.
Sponsored by ClinAmygate · Phase 4, Interventional, and Treatment
Time to recover of Anosmia and / or ageusia and early corticosteroid use
In a study of dexamethasone kinetics in two groups of 15 patients with community-acquired pneumonia, one group was treated with dexamethasone 6 mg/day by mouth and the other with 4 mg/day intravenously. The apparent volume of distribution was 1 L/kg in both groups, but the half-life after oral administration was approximately 7 hours, and after intravenous administration 9 hours. The bioavailability of oral dexamethasone was 81% (95% CI = 54-121%). However, the biological half-life of dexamethasone is much longer, of the order of 36-54 h compared with 18-36 h for prednisolone.
Time to recover of Anosmia and / or ageusia and early corticosteroid use
Exclusion Criteria:
early use of dexamethasone as early as the laboratory confirmation of inflammation.
Drug: Early-Dexamethasone
Dexamethasone is to be used lately upon the deterioration of cases
Drug: Late dexamethazone
early use of dexamethasone as early as laboratory evidence of high inflammatory markers
Also known as: Dexamethasone
Use of dexamethasone on deterioration of the cases with increased severity
Also known as: Dexamethasone
Time to recovery
Time to recovery from anosmia and / or agusia
Time frame: one to 6 weeks
Plan to share: No
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
ClinAmygate