ClinicalTrials.gg
Enrolling by invitationNCT07527871ED-SMARTUpdated Jul 23, 2026

Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

An interventional study of ED-SMART intervention and Substance use information in Substance Use (Drugs, Alcohol), sponsored by Purdue University. Enrolling by invitation at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-23.

Sponsored by Purdue University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
650
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner Medical Center.

02

Conditions studied

  • Substance Use (Drugs, Alcohol)

Keywords

  • substance use
03

In context

Substance-Related Disorders

2,238 studies on the registry are indexed under Substance-Related Disorders; 409 are open to participants now.

This study's planned enrollment of 650 is above the median of 108 across 1,840 interventional studies indexed under Substance-Related Disorders.

Browse Substance-Related Disorders studies →

Lead sponsor

Purdue University is the lead sponsor of 175 studies on the registry; 21 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult at least 18 years of age
  • Capacity and willingness to participate (including reliable phone or internet access for counseling session)
  • Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk.

Exclusion criteria

Exclusion Criteria:

  • A priori participant request for participation
  • Previously enrolled in this or other study of substance use disorder prevention
  • Language other than English
  • Expected/actual ED disposition of hospitalization or non-independent status
  • Prisoner at time of enrollment
  • Known to be pregnant at time of enrollment
  • Past substance use disorder or substance use treatment
  • High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
650 participants (estimated)

Study arms

  • Experimental
    ED-SMART intervention

    The ED-SMART intervention includes: (i) a brief (approximately 15 minutes) counseling session in the emergency department and (ii) five, monthly brief counseling sessions (approximately 15 to 30 minutes) delivered by telehealth. These sessions will focus on creating individualized strategies to help participants reach their alcohol and substance use reduction goals.

    Behavioral: ED-SMART intervention

  • Placebo comparator
    Substance use information

    The substance use information condition will receive printed health information covering information about substance use (e.g., definitions, hazards, potential for addiction, injury, and other consequences). Staff will also discuss ways to utilize primary care or establish care with a primary care provider to provide ongoing follow-up.

    Behavioral: Substance use information

Interventions

  • BehavioralED-SMART intervention

    The ED-SMART intervention will include: (i) a brief (approximately 15 minutes) counseling session in the emergency department and (ii) five, monthly brief counseling sessions (approximately 15 to 30 minutes) delivered by telehealth. These sessions will focus on creating individualized strategies to help participants reach their alcohol and substance use reduction goals

  • BehavioralSubstance use information

    The substance use information condition will receive printed health information covering information about substance use (e.g., definitions, hazards, potential for addiction, injury, and other consequences). Research staff will also discuss ways to utilize primary care or establish care with a primary care provider to provide ongoing follow-up.

06

What researchers measure

Primary outcomes

  1. Self-reported substance use

    Self-reported substance use frequency

    Time frame: From baseline to the sixth month follow-up assessment

Secondary outcomes

  1. Self-reported substance use quantity

    Self-reported substance use quantity for each substance

    Time frame: From baseline to the six month follow-up

  2. Incidence of positive substance use disorder screen

    Incidence of positive substance use disorder screen as measured by the NIDA Modified ASSIST or AUDIT

    Time frame: From baseline to the six month follow-up

  3. Toxicology assays for substance use

    Proportion with positive toxicology assay for substance use

    Time frame: From baseline to the six month follow-up assessment

  4. Self-reported healthcare utilization

    Self-reported healthcare utilization

    Time frame: Baseline to the six month follow-up assessment

  5. Fatal and non-fatal overdose

    Frequency of fatal and non-fatal overdose

    Time frame: Baseline to the six month follow-up assessment

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 23, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07527871
Lead sponsor
Purdue University
Responsible party
BrownLab (Professor, Purdue University) — Principal investigator
First posted
Apr 14, 2026
Start date
Jun 17, 2026
Primary completion
Sep 2029 (estimated)
Completion
Sep 2029 (estimated)
Last update
Jul 23, 2026

Study contacts

Jennifer L. Brown, PhD
principal investigator · Purdue University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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