An observational study in Idiopathic Nephrotic Syndrome, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 6 Months to 16 Years. Per ClinicalTrials.gov, last updated 2017-03-27.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
The primary purpose of the study is to identify the factors of steroid dependency in childhood idiopathic nephrotic syndrome. The steroid dependency is defined by a relapse of nephrotic syndrome within the 3 weeks that follow the withdrawal of steroid therapy after the first manifestation. Different clinical and biological factors will be analyzed: age of first manifestation, delay of remission, ethnicity, and preceding viral infection, geolocalization in the Parisian area, genoprevalence of herpes viruses and polymorphisms in the genes involved in the response to steroid therapy.
Patients with a steroid dependent nephrotic syndrome will be compared to those with a non steroid dependent form of nephrotic syndrome at the end of the first manifestation. An additional blood volume will be sampled in patients and controls during a scheduled biological check-up for the initial disease. Genetics factors will be checked using a DNA chips devoted to the response to steroid therapy and viral genome of EBV, CMV, HHV7 will be searched for using PCR reaction in total blood DNA extract.
192 studies on the registry are indexed under Nephrotic Syndrome; 63 are open to participants now.
This study's enrollment of 351 is above the median of 136 across 60 observational studies indexed under Nephrotic Syndrome.
Browse Nephrotic Syndrome studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Any children below 16 years of age with a first manifestation of idiopathic nephrotic syndrome commencing or having commenced in the Paris area
Exclusion Criteria:
children below 16 years of age with a steroid dependent nephrotic syndrome
Genetic: DNA chip dedicated to the pharmacogenetic of steroids
direct DNA extraction from peripheral blood cells
define pharmacogenetic factors of steroid dependency
Time frame: 28.5 months
parameters of the immune response against herpesvirus, specially the cellular production of interferon induced by specific viral peptides
Time frame: 28.5 months
Dynamic of the epidemiology of idiopathic nephrotic syndrome in the Paris Area
Number of participants with idiopathic nephrotic syndrome in Paris Area to determinate if clusters cases exist.
Time frame: 28.5 months
Analysis of cortico-dependence factors
Comparison of polymorphisms of cortico-dependent patients with non- cortico-dependent patients
Time frame: Day 1
Analysis of susceptibility factors that generate the appearance of the Idiopathic Nephrotic Syndrome
Comparison of polymorphisms of all patients suffering from the Idiopathic Nephrotic Syndrome, with general population
Time frame: Day 1
This study is completed, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris