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CompletedNCT01604551Updated Jun 1, 2012

Membrane Shedding During Septic Shock

An observational study in Septic Shock, sponsored by University Hospital, Strasbourg, France. Completed at 3 sites in France. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2012-06-01.

Sponsored by University Hospital, Strasbourg, France · Observational

Study type
Observational
Time perspective
Prospective
Enrollment
100
Ages
18 Years to 85 Years
Sex
All
01

Study summary

Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This is a prospective observational study of circulating MPs and blood coagulation in 100 septic shock patients admitted in 3 tertiary hospitals medical ICU at baseline (D1), D2, D3, D4 and D7.

02

Conditions studied

  • Septic Shock

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03

In context

Shock, Septic

890 studies on the registry are indexed under Shock, Septic; 210 are open to participants now.

This study's enrollment of 100 is close to the median of 100 across 309 observational studies indexed under Shock, Septic.

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Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 989 studies on the registry; 348 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with septic shock

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Septic shock
  • Informed consent

Exclusion criteria

Exclusion Criteria:

  • Class IV heart failure
  • Child-Plugh grade C cirrhosis
  • Cancer under active treatment
  • BMI>35 kg/m²
  • Moribund patient
  • DNR decision
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Study design

Time perspective
Prospective
Enrollment
100 participants (actual)
06

Study locations

3 sites
  • Service Réanimation Médicale et Médecine Hyperbare, CHU
    Angers, 49933, France
  • Centre Hospitalier
    Mulhouse, 68070, France
  • Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires
    Strasbourg, 67091, France
07

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of May 2003 and a completion of Dec 2011. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
May 21, 2012
First posted
May 23, 2012
Start
May 2003
CompletionActual
Dec 2011
Last update
Jun 1, 2012
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 1, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01604551
Responsible party
Sponsor
First posted
May 23, 2012
Start date
May 2003
Completion
Dec 2011
Last update
Jun 1, 2012

Study contacts

Xavier DELABRANCHE, MD
principal investigator · Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, France

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2012. You cannot join it, but the record below documents what was studied.

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Discussion

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