A Phase 3 interventional study of Cyclosporine A and cardio-pulmonary resuscitation in Non Shockable Out of Hospital Cardiac Arrest, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-08-28.
Sponsored by Hospices Civils de Lyon · Phase 3, Interventional, and Treatment
The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.
966 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.
This study's enrollment of 796 is above the median of 100 across 557 interventional studies indexed under Heart Arrest.
Browse Heart Arrest studies →Hospices Civils de Lyon is the lead sponsor of 1,826 studies on the registry; 439 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation
Drug: Cyclosporine A · Procedure: cardio-pulmonary resuscitation
usual care of cardiac arrest
Procedure: cardio-pulmonary resuscitation
Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation
usual care of cardiac arrest
Sequential Organ Failure Assessment score (SOFA)
Time frame: At 24 hours after hospital admission
Hospital admission with return of spontaneous circulation
Time frame: At 24 hours following admission, at day 28, at hospital discharge (an average time frame of 7 days)
Survival
Time frame: At 24 hours following admission, at day 28, and at hospital discharge (an average time frame of 7 days)
Good cerebral outcome
Glasgow Coma Scale and Cerebral Performance Categories
Time frame: At 24 hours following admission, at day 28, and at hospital discharge (an average time frame of 7 days)
All adverse events
Time frame: until hospital discharge (an average time frame of 7 days)
This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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Hospices Civils de Lyon