CClinicalTrials.gg
CompletedNCT01575158Updated Apr 11, 2012

Citalopram vs Clomipramine vs Placebo in Recurrent Depression

An interventional study of Citalopram and Clomipramine in Depression, sponsored by University of Aarhus. Completed. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2012-04-11.

Sponsored by University of Aarhus · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
59
Allocation
Randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

citalopram and clomipramine are better than placebo in preventing new episodes of depression in patients with recurrent depression

02

Conditions studied

03

In context

Depression

8,057 studies on the registry are indexed under Depression; 1,643 are open to participants now.

This study's enrollment of 59 is below the median of 84 across 6,718 interventional studies indexed under Depression.

Browse Depression studies →

Lead sponsor

University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients with recurrent depression
  • Sustained response achieved (3 consecutive monthly ratings at the HDS below 13)after a treatment requiring index episode

Exclusion criteria

Exclusion Criteria:

  • Contraindications to study medications
  • Pregnancy
  • Substance abuse
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
59 participants (actual)

Study arms

  • Experimental
    citalopram

    citalopram

    Drug: Citalopram

  • Active comparator
    clomipramnine

    clomipramine

    Drug: Clomipramine

  • Placebo comparator
    placebo

    placebo

    Drug: placebo

Interventions

  • DrugCitalopram
  • DrugClomipramine
  • Drugplacebo
06

What researchers measure

Primary outcomes

  1. 2 Hamilton Depression Rating Scale scores of at least 16 with one weeks interval or initiation of another antidepressant treatment

    Time frame: 2 years of follow-up

Secondary outcomes

  1. Study termination due to adverse event or non-compliance

    Time frame: 2 years of follow-up

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 11, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01575158
Lead sponsor
University of Aarhus
Collaborators
Danish University Antidepressant Group
Responsible party
Sponsor
First posted
Apr 11, 2012
Start date
Oct 1997
Primary completion
Sep 2007
Completion
Sep 2007
Last update
Apr 11, 2012

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2012. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion