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Status unknownNCT01547039Updated Mar 12, 2012

Platelet Reactivity and MES During CEA

An observational study in Carotid Artery Stenosis, Ischemic Stroke and Myocardial Infarction, sponsored by UMC Utrecht. Status unknown at 1 site in Netherlands. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2012-03-12.

Sponsored by UMC Utrecht · Observational

The sponsor has not verified this record recently (last verified Mar 2012), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
18 Years to 90 Years
Sex
All
01

Study summary

The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).

02

Conditions studied

  • Carotid Artery Stenosis
  • Ischemic Stroke
  • Myocardial Infarction
  • Aspirin Resistance

Keywords

  • Carotid endarterectomy
  • Transcranial doppler
  • Micro embolic signals
  • Platelets
  • Aspirin
03

In context

Ischemic Stroke

2,593 studies on the registry are indexed under Ischemic Stroke; 930 are open to participants now.

This study's planned enrollment of 200 is below the median of 300 across 777 observational studies indexed under Ischemic Stroke.

Browse Ischemic Stroke studies →

Lead sponsor

UMC Utrecht is the lead sponsor of 350 studies on the registry; 80 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

patients undergoing elective carotid endarterectomy in University Medical Centre Utrecht

Inclusion criteria

  • Al patients undergoing elective carotid endarterectomy

Exclusion criteria

Exclusion Criteria:

  • Patients requiring a blood transfusion prior to surgery
  • Patients with an inappropriate temporal bone window for transcranial Doppler (TCD)
  • Patients on vitamin K antagonists or antiplatelet treatment other then aspirin
  • Patients with an artificial cardiac valve
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Biospecimen retention
Samples without dna

Groups and cohorts

  • Carotid endarterectomy (CEA)

    Patients undergoing carotid endarterectomy

06

What researchers measure

Primary outcomes

  1. Microembolic signals (MES)

    Microembolic signals detected by transcranial duplex (TCD)

    Time frame: During and 1 hour following carotid endarterectomy (CEA)

Secondary outcomes

  1. Ischemic stroke

    Time frame: within 30 days postoperative

  2. Asymptomatic perioperative myocardial injury

    Troponin elevation \> 0.1 ng/ml

    Time frame: 3 days postoperative

  3. Myocardial infarction

    Time frame: Within 30 days postoperative

07

Study locations

1 site
  • UMC Utrecht
    Utrecht, 3584CX, Netherlands
    • Gert Jan de Borst, MD, PhD · Contact · G.J.deBorst-2@umcutrecht.nl · 0031887556965
    • Gert Jan de Borst, MD, PhD · Principal investigator
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 12, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01547039
Lead sponsor
UMC Utrecht
Responsible party
Gert Jan de Borst (MD, PhD, UMC Utrecht) — Principal investigator
First posted
Mar 7, 2012
Start date
Jun 2012
Primary completion
Jun 2014 (estimated)
Completion
Jul 2014 (estimated)
Last update
Mar 12, 2012

Study contacts

Gert Jan de Borst, MD, PhD
principal investigator · UMC Utrecht

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Mar 2012. You cannot join it, but the record below documents what was studied.

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