An interventional study of Laser therapy and Placebo laser therapy in Chronic Obstructive Pulmonary Disease and Fatigue, sponsored by Eduardo Foschini Miranda. Status unknown at 1 site in Brazil. Open to participants aged 40 Years to 90 Years. Per ClinicalTrials.gov, last updated 2013-09-04.
Sponsored by Eduardo Foschini Miranda · Not applicable, Interventional, and Treatment
Light-emitting diodes (LEDs) have been used to minimize muscle fatigue in athletes and healthy subjects. Patients with chronic obstructive pulmonary disease (COPD) are susceptible to early muscle fatigue. The objective of this study is to assess the acute effects of LEDs on muscle function, exercise capacity, and cardiorespiratory responses during isometric and dynamic exercise in patients with COPD. This study will assess 30 patients with moderate to severe obstruction (FEV1 ≤ 70% predicted). Isometric and dynamic protocols will be conducted in two visits each, for a total of four visits a week a part. First, a venous blood sample will be taken from the patients. The isometric protocol will start with the determination of the maximum voluntary isometric contraction (MIVC) to determine the workload (60% of MIVC) for the isometric endurance test (IET). Patients will be randomized to receive either the placebo or LED application. Immediately after finishing this procedure, the patients will carry out the IET until the limit of tolerance or until a 20% fall of strength is observed. After the test, another blood sample will be taken. In the other visit (one week later), the same order of procedures will be performed, except with the opposite (LED or placebo). For the dynamic protocol, the same procedures described above will be followed except with the maximal incremental cycle ergometer test used instead of the IET. The electromyography will be recorded during the isometric and dynamic protocols. Differences in muscle function, exercise capacity, and cardiorespiratory responses between the LED and placebo applications will be analyzed. The therapeutic effects of LED could minimize muscle fatigue in patients with COPD by increasing exercise tolerance.
3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.
This study's planned enrollment of 27 is below the median of 72 across 2,118 interventional studies indexed under Lung Diseases.
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Exclusion Criteria:
Recently has been using the LED, known by its acronym in English LED (Light Emitting Diode), devices that are light-emitting non-coherent and monochromatic, having a longer wavelength (± 10 - 30 nm) compared to lasers. The difference between the fundamental radiation emitted by a laser and an LED is the coherence of the beam.
Other: Laser therapy
Other: Placebo laser therapy
The therapeutic effects of low intensity lasers are: (i) analgesic and anti-inflammatory, (ii) regeneration, (iii) tissue healing and (vi) recovery from muscle fatigue.
Also known as: (Light Emitting Diode)
The application of laser therapy will be a low intensity laser.
Analysis of the recovery time for the isometric and dynamic protocol
Time frame: Measures muscular endurance will be compared after a period of 1 week.
Analysis of lactate levels and the activity of CK and C-reactive protein (CRP).
Time frame: Measures blood will be compared after a period of 1 week.
This study is status unknown, as verified in Sep 2013. You cannot join it, but the record below documents what was studied.
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