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CompletedNCT01397773Updated Jul 20, 2011

Pentraxin-3 in Chronic Renal Failure

An observational study in Inflammation and Chronic Kidney Disease, sponsored by Haseki Training and Research Hospital. Completed at 1 site in Turkey. Open to participants aged 16 Years to 80 Years. Per ClinicalTrials.gov, last updated 2011-07-20.

Sponsored by Haseki Training and Research Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
85
Ages
16 Years to 80 Years
Sex
All
01

Study summary

The aim of the study is to measure Pentraxin-3 levels in patients on hemodialysis, peritoneal dialysis and those in the pre-dialysis period; and to compare these groups with the control group; so as to investigate the eligibility of it as a reliable marker of inflammation; relationship with other inflammatory markers and carotis intima media thickness.

Read the detailed description

The investigators planned to involve four group of patients: Hemodialysis, peritoneal dialysis, pre-dialysis and the control group; with about 25 patients planned to be involved in each group. The laboratory parameters to be measured are Pentraxin-3, C-reactive protein (CRP), high sensitive CRP, fibrinogen and interleukin-6. Concomitantly, carotis intima media thickness will be measured in the radiology clinic. Statistical analysis will be carried on by Statistical Package for Social Sciences (SPSS) for Windows 13.0. The variables acting on the inflammatory parameters and the correlation between them and carotis intima media thickness will be studied.

02

Conditions studied

  • Inflammation
  • Chronic Kidney Disease

Keywords

  • Hemodialysis
  • peritoneal dialysis
  • chronic kidney disease
  • inflammation
  • carotis intima media thickness
03

In context

Kidney Diseases

3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.

This study's planned enrollment of 85 is below the median of 192 across 1,033 observational studies indexed under Kidney Diseases.

Browse Kidney Diseases studies →

Lead sponsor

Haseki Training and Research Hospital is the lead sponsor of 75 studies on the registry; 15 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
16 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients will be selected among those who are followed up in our clinic.

Inclusion criteria

  • To give informed consent
  • Hemodialysis or peritoneal dialysis for more than 3 months
  • Creatinin clearance less than 30 ml/min for the pre-dialysis group

Exclusion criteria

Exclusion Criteria:

  • Not to give informed concent
  • Active infection within the last 3 months
  • Known chronic inflammatory disease
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
85 participants (estimated)
Biospecimen retention
Samples without dna

Groups and cohorts

  • Hemodialysis group

    Patients on chronic hemodialysis program

  • Peritoneal dialysis group

    Patients on chronic peritoneal dialysis program

  • Pre-dialysis group

    Patients with chronic kidney disease stage-4

  • Control group

    Healthy subjects

06

What researchers measure

Primary outcomes

  1. Pentraxin-3 level

    Pentraxin-3 level will be compared with other inflammatory markers.

    Time frame: Five months

Secondary outcomes

  1. Carotis intima media thickness

    Correlation of Pentraxin-3 and carotis intima media thickness

    Time frame: Five months

07

Study locations

1 site
  • Haseki Training and Research Hospital
    Istanbul, 34390, Turkey
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 20, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01397773
Lead sponsor
Haseki Training and Research Hospital
First posted
Jul 20, 2011
Start date
Apr 2010
Primary completion
Jan 2011
Completion
Jan 2011
Last update
Jul 20, 2011

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jul 2011. You cannot join it, but the record below documents what was studied.

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