An observational study in Hernia, Inguinal and Inguinal Hernia, sponsored by Haseki Training and Research Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-16.
Sponsored by Haseki Training and Research Hospital · Observational
The goal of this observational study is to learn how the length of pneumoperitoneum during laparoscopic inguinal hernia surgery may affect changes in blood bicarbonate levels. Pneumoperitoneum is the use of carbon dioxide gas to create space inside the abdomen during laparoscopic surgery.
The main question this study aims to answer is whether a longer pneumoperitoneum time is associated with changes in blood bicarbonate levels after surgery.
Participants are adults undergoing laparoscopic inguinal hernia repair as part of their routine medical care. Researchers will measure blood gas values, including bicarbonate levels, before surgery and again two hours after surgery. The change in bicarbonate levels will be compared with the duration of pneumoperitoneum during the operation.
The results of this study may help improve the understanding of metabolic changes that occur during laparoscopic surgery.
Carbon dioxide pneumoperitoneum is routinely used during laparoscopic surgery to provide adequate visualization and working space. However, absorption of carbon dioxide and increased intra-abdominal pressure may influence acid-base balance during the perioperative period. These physiological changes may be reflected in blood gas parameters such as pH, partial pressure of carbon dioxide (pCO2), and serum bicarbonate levels.
This prospective observational study aims to evaluate the relationship between pneumoperitoneum duration and perioperative changes in serum bicarbonate levels in patients undergoing laparoscopic inguinal hernia repair using the transabdominal preperitoneal (TAPP) technique.
Adult patients undergoing elective laparoscopic inguinal hernia repair will be included in the study. Blood gas measurements will be obtained before surgery and at the second postoperative hour. Serum bicarbonate levels will be recorded, and the difference between preoperative and postoperative measurements (ΔHCO3-) will be calculated.
The primary outcome of the study is the change in serum bicarbonate levels between the preoperative and postoperative second-hour measurements. Secondary outcomes include postoperative pain scores, postoperative acid-base parameters such as pH and pCO2, and early postoperative complications within the first 24 hours.
Pneumoperitoneum duration will be recorded intraoperatively and analyzed for its association with perioperative metabolic changes. The findings of this study may contribute to a better understanding of metabolic alterations occurring during laparoscopic surgery and their potential clinical implications.
549 studies on the registry are indexed under Hernia, Inguinal; 74 are open to participants now.
This study's planned enrollment of 100 is below the median of 150 across 133 observational studies indexed under Hernia, Inguinal.
Browse Hernia, Inguinal studies →Haseki Training and Research Hospital is the lead sponsor of 75 studies on the registry; 15 are open to participants now.
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Adult patients undergoing laparoscopic inguinal hernia repair (TAPP) at Haseki Training and Research Hospital will be included. Perioperative pneumoperitoneum duration and serum bicarbonate changes will be analyzed using blood gas measurements obtained preoperatively and at the second postoperative hour.
Exclusion Criteria:
Adult patients undergoing laparoscopic inguinal hernia repair (TAPP). Pneumoperitoneum duration and perioperative serum bicarbonate changes will be analyzed using blood gas measurements obtained preoperatively and at the second postoperative hour.
Procedure: Laparoscopic Inguinal Hernia Repair (TAPP)
Standard laparoscopic inguinal hernia repair performed using the transabdominal preperitoneal (TAPP) technique as part of routine clinical care. Pneumoperitoneum duration during the procedure will be recorded for analysis.
Change in Serum Bicarbonate Level
Difference between preoperative and postoperative second-hour serum bicarbonate levels measured by blood gas analysis in patients undergoing laparoscopic inguinal hernia repair. Unit of Measure: mmol/L
Time frame: Preoperative to postoperative 2 hours
Postoperative Pain Score
Postoperative pain intensity measured using the Visual Analog Scale (VAS). The scale ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores represent greater pain severity. Unit of Measure: VAS score (0-10)
Time frame: Within 24 hours after surgery
Change in Arterial Blood pH
Change in arterial blood pH measured during pneumoperitoneum. Unit of Measure: pH
Time frame: Preoperative to postoperative 2 hours
Early Postoperative Complications
Early postoperative complications occurring within the first 24 hours after laparoscopic inguinal hernia repair.
Time frame: Within 24 hours
Change in Arterial Partial Pressure of Carbon Dioxide
Change in arterial PaCO₂ levels measured intraoperatively. Unit of Measure: mmHg
Time frame: Preoperative to postoperative 2 hours
Plan to share: No — Individual participant data will not be shared due to institutional data protection policies and patient confidentiality requirements. Only aggregated and anonymized data will be reported in scientific publications.
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Haseki Training and Research Hospital