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CompletedNCT01322568Updated Nov 12, 2019

Research on Aging Project in Iceland: Second Stage

An observational study in Atherosclerosis, Osteoporosis and Obesity, sponsored by National Institute on Aging (NIA). Completed at 1 site in Iceland. Open to participants aged 32 Years to 60 Years. Per ClinicalTrials.gov, last updated 2019-11-12.

Sponsored by National Institute on Aging (NIA) · Observational

Study type
Observational
Time perspective
Prospective
Enrollment
5,764
Ages
32 Years to 60 Years
Sex
All
01

Study summary

Background:

  • Researchers are interested in studying the environmental and genetic factors that play a role in health and living conditions as people age. Since 2002, the U.S. National Institute on Aging and the Icelandic Heart Association Research Institute have been conducting a long-term study known as the Research in Aging project to collect personal data and samples from Icelandic men and women in order to study risk factors related to disease and disability in old age. Researchers plan to initiate a second stage of the study.

Objectives:

  • To collect additional personal information, medical records, and blood samples from individuals who have previously provided materials for the Research in Aging Project in Iceland.

Eligibility:

  • Individuals who have previously participated in the Research in Aging project in association with the U.S. National Institute on Aging and the Icelandic Heart Association Research Institute.

Design:

  • Participants will have a physical examination with imaging analysis procedures and hearing and eye tests, provide information on health and diet, and provide a 100-ml blood sample for testing.
  • Participants will also provide consent for researchers to consult data and samples collected during the first stage of the Research on Aging project.
Read the detailed description

In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES) was initiated in 2002. AGES was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relation to disease and disability in old age. The study is multidisciplinary, providing detailed phenotypes related to the cardiovascular, neurocognitive (including sensory), and musculoskeletal systems, and to body composition and metabolic regulation. Relevant quantitative traits, subclinical indicators of disease, and medical diagnoses are identified by using biomarkers, imaging, and other physiologic indicators. The AGES sample is drawn from an established population-based cohort, the Reykjavik Study. This cohort of men and women born between 1907 and 1935 has been followed in Iceland since 1967 by the Icelandic Heart Association. The AGES cohort, with cardiovascular risk factor assessments earlier in life and detailed late- life phenotypes of quantitative traits, will create a comprehensive study of aging nested in a relatively genetically homogeneous older population. This approach should facilitate identification of genetic factors that contribute to healthy aging as well as the chronic conditions common in old age.

02

Conditions studied

  • Atherosclerosis
  • Osteoporosis
  • Obesity
  • Glucose Abnormalities
  • Alzheimer's Disease
  • Vascular Dimentia

Keywords

  • Aging
  • Gene
  • Environment
  • Inflammation
  • Iceland
03

In context

Osteoporosis

1,640 studies on the registry are indexed under Osteoporosis; 212 are open to participants now.

This study's enrollment of 5,764 is above the median of 174 across 446 observational studies indexed under Osteoporosis.

Browse Osteoporosis studies →

Lead sponsor

National Institute on Aging (NIA) is the lead sponsor of 157 studies on the registry; 13 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 2 (29%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
32 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

  • INCLUSION CRITERIA:

Individuals who have previously participated in the Research in Aging project in association with the U.S. National Institute on Aging and the Icelandic Heart Association Research Institute.

05

Study design

Time perspective
Prospective
Enrollment
5,764 participants (actual)
06

Study locations

1 site
  • Icelandic Heart Association Research Institute
    Kopavogur, Iceland
07

References and documents

Publications

  • Freimer N, Sabatti C. The human phenome project. Nat Genet. 2003 May;34(1):15-21. doi: 10.1038/ng0503-15. No abstract available. PubMed 12721547 ↗
  • Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999 Jan 14;340(2):115-26. doi: 10.1056/NEJM199901143400207. No abstract available. PubMed 9887164 ↗
  • Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-70. doi: 10.1146/annurev.med.51.1.245. PubMed 10774463 ↗
  • Schelbert EB, Cao JJ, Sigurdsson S, Aspelund T, Kellman P, Aletras AH, Dyke CK, Thorgeirsson G, Eiriksdottir G, Launer LJ, Gudnason V, Harris TB, Arai AE. Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. JAMA. 2012 Sep 5;308(9):890-6. doi: 10.1001/2012.jama.11089. PubMed 22948699 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 12, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01322568
Lead sponsor
National Institute on Aging (NIA)
Responsible party
Sponsor
First posted
Mar 24, 2011
Start date
Jan 31, 2003
Completion
Feb 11, 2014
Last update
Nov 12, 2019

Study contacts

Tamara B Harris, M.D.
principal investigator · National Institute on Aging (NIA)
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2014. You cannot join it, but the record below documents what was studied.

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