ClinicalTrials.gg
RecruitingNCT01324206Updated Nov 9, 2026

Development of 3T Magnetic Resonance Research Methods for NIA Studies

An observational study in Normal Physiology, sponsored by National Institute on Aging (NIA). Recruiting at 1 site in United States. Open to participants aged 18 Years to 99 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-09.

Sponsored by National Institute on Aging (NIA) · Observational

From the registry’s dates

  • Started Nov 2008; still recruiting 18 years later.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
1,000
Ages
18 Years to 99 Years
Sex
All
01

Study summary

Background:

- Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the brain, muscles, joints, heart, and blood vessels. Scientific applications of MRI scans often use techniques that need to be modified or refined before they are used in clinical studies. To develop and modify these techniques for the new Philips 3T Achieva whole-body MRI scanner, researchers are interested in conducting trial MRI scans on healthy individuals and individuals with conditions that require imaging studies.

Objectives:

- To conduct preliminary trials of the 3T MRI facility to develop and refine MRI scanning procedures.

Eligibility:

- Individuals at least 18 years of age who are able to have magnetic resonance imaging.

Design:

  • Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
  • Participants will have an MRI scan using the 3T scanner. Some scans may require the use of a contrast agent or radiotracer, which is a small amount of radioactive substance that will be injected before the start of the scan. Some participants may be asked to perform tasks of thinking and movement while in the scanner, in order to test the procedures required for a functional MRI scan.
  • No treatment will be provided as part of this protocol.
Read the detailed description

Study Description:

The purpose of this protocol is to permit use of the magnetic resonance imaging (MRI) facility for the development and refinement of MRI and spectroscopy (MRIS) scanning procedures. The information obtained through these methodological assessments will be essential future clinical research investigations conducted through the NIA under specific protocols. Additionally, this data can be utilized in already approved NIA studies for comparison purposes.

Objectives:

Primary Objective: To develop and refine specific MR imaging and spectroscopy methods.

Secondary Objectives: To allow pilot tests of procedures for development and refinement of motor or cognitive activation paradigms.

Endpoints:

Development of noninvasive MR biomarkers to assess longevity, healthy longevity, physical disability, cognitive impairment, and frailty.

02

Conditions studied

  • Normal Physiology

Keywords

  • Magnetic Resonance Imaging
  • Healthy Volunteers
  • Natural History
03

In context

Lead sponsor

National Institute on Aging (NIA) is the lead sponsor of 160 studies on the registry; 13 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 2 (29%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 99 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Healthy volunteers, male and female, 18yrs and older

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

To be eligible to participate in this study, an individual must meet all the following criteria:

  • Ability of subject to understand the study and stated willingness to comply with all study procedures.
  • Male or female, age > 18years.
  • Able to speak and read English.
  • Capable of providing .
  • Subjects or persons identified by an investigator to have a condition of interest for exploratory studies as it relates to aging. These participants are not being scanned for diagnostic purposes.

Exclusion criteria

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

  • Has condition and/or non-removable device for MRI as per the MRI eligibility form.
  • Weight > 300lbs (MRI scanner weight limit)
  • Is currently pregnant or a nursing mother.
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
1,000 participants (estimated)

Groups and cohorts

  • Healthy Volunteers

    Healthy Volunteers, 18 or older years

06

What researchers measure

Primary outcomes

  1. Develop and refine scanning procedures

    To develop and refine specific imaging and spectroscopic methods.

    Time frame: 2 months

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: Undecided — There is ongoing discussion within the NIA IRP and a plan has not been finalized yet.

09

Timeline

Tracking since Sep 25, 2026

Started Nov 2008 (actual).

How these figures are worked out, and which studies are left out of them.

Registered
Mar 25, 2011
First posted
Mar 28, 2011
StartActual
Nov 3, 2008
Last update
Nov 9, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Nov 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01324206
Responsible party
Sponsor
First posted
Mar 28, 2011
Start date
Nov 3, 2008
Last update
Nov 9, 2026

Study contacts

Seung-Ho Park, R.N.
Contact
sarah.park@nih.gov
(410) 350-7315
Mustapha Bouhrara, Ph.D.
Contact
bouhraram@mail.nih.gov
(410) 558-8541
Mustapha Bouhrara, Ph.D.
principal investigator · National Institute on Aging (NIA)

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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