An interventional study of partial blood flow restriction and Low intensity exercise without partial blood flow restriction in Knee Osteoarthritis and Symptomatic Knee Osteoarthritis, sponsored by University of Iowa. Completed at 1 site in United States. Open to female participants aged 45 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-06-28.
Sponsored by University of Iowa · Not applicable and Interventional
The objective of the proposed research is to assess the efficacy of an eight-week, efficient and tolerable, low-intensity resistance-training program with concurrent application of partial blood flow restriction (PBFR) for improving quadriceps strength and volume in women with risk factors for incident symptomatic or progressive knee OA. This specific aim will be achieved through a randomized, controlled trial, comparing low intensity training with and without PBFR. There have been numerous reports of exercise interventions in people with knee osteoarthritis. However, this research is novel in that it will be the first to use a low intensity regimen that will minimize forces on the knee while still having the potential to lead to clinically meaningful strength gains in older adults with risk factors for incident symptomatic or progressive knee OA.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's enrollment of 50 is below the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →University of Iowa is the lead sponsor of 276 studies on the registry; 35 are open to participants now.
Of its 44 completed or terminated interventional studies of FDA-regulated products, 39 (89%) have results posted.
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Exclusion Criteria:
Partial Blood Flow Restriction (PBFR) during Low-Intensity Exercise.
Other: partial blood flow restriction
Low-Intensity Exercise without partial blood flow restriction.
Other: Low intensity exercise without partial blood flow restriction
Partial Blood Flow Restriction (PBFR) Low-Intensity Exercise: using the Biodex 3 Dynamometer in isotonic mode at 10% (first 3 weeks), 15% (following 3 weeks) and 20% (final 3 weeks) of their 1RM for each side, while receiving PBFR in each exercising limb. The padded belts (65 mm in width and 650 mm in length) of the Kaatsu Master™ PBFR device (Sato Sports Plaza, Tokyo, Japan) will be applied to the proximal thigh as near to the hip joint as is comfortable. Before training each leg, subjects will be seated in a chair where an initial belt pressure of 37-40 mmHg will be applied. The belt then will be iteratively pressurized for 30 seconds and then relaxed for 10 seconds in increments of 20 mmHg from 100 mmHg to the final pressure of 160 mmHg. During exercise, the cuff pressure will be continuously controlled and monitored by the PBFR apparatus
Low-Intensity Exercise: using the Biodex 3 Dynamometer in isotonic mode at 10% (first 3 weeks), 15% (following 3 weeks) and 20% (final 3 weeks) of their 1RM for each side in each exercising limb without partial blood flow restriction.
Change in isokinetic knee extensor strength after 9-week intervention
This outcome will measure efficacy of 9-week intervention.
Time frame: Outcome will be measured at week 0 (baseline) and approximately 10 weeks later (after completion of 9-week intervention)
Change in quadriceps volume assessed by MRI after completion of 9-week intervention
This outcome will measure efficacy of the 9-week intervention.
Time frame: outcome will be measured at week 0 and at approximately week 10 (after completion of 9-week intervention)
This study is completed, as verified in Jun 2011. You cannot join it, but the record below documents what was studied.
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University of Iowa