A Phase 2 interventional study of Intranasal naloxone and Intravenous in Morphinan Opioid Overdose, sponsored by Isfahan University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 15 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-02-10.
Sponsored by Isfahan University of Medical Sciences · Phase 2, Interventional, and Treatment
The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients
In intravenous drug abusers (IDUs), as a result of previous intravenous substance abuse, the predictable difficult cannulate exist and cause the delay administration of antidote therapy. Additionally, IDUs are also at increased risk of carrying blood borne infections that could be transmitted to healthcare workers through needle stick injuries. The investigators aimed to compare intranasal administration of naloxone with intravenous route.
139 studies on the registry are indexed under Drug Overdose; 24 are open to participants now.
This study's enrollment of 100 is close to the median of 100 across 98 interventional studies indexed under Drug Overdose.
Browse Drug Overdose studies →Isfahan University of Medical Sciences is the lead sponsor of 145 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with the range of 15-50 years old
Exclusion Criteria:
The investigators administered intravenous naloxone for our opioid overdose patients
Drug: Intravenous
The investigators administered intranasal naloxone for treatment of our patients
Drug: Intranasal naloxone
spray naloxone, 0.4 mg/ each 4 minutes till increasing patient level of consciousness
Amp naloxone, 0.4 mg / each 4 minutes till increasing patient level of consciousness
level of consciousness
The investigators evaluated the level of consciousness with Glasgow coma sclae 4 minutes after naloxone administration
Time frame: 4 min after naloxone administration
blood pressure
The investigators evaluated blood pressure 4 minutes after naloxone administration
Time frame: at 4 min after naloxone administration
This study is completed, as verified in Mar 2007. You cannot join it, but the record below documents what was studied.
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Isfahan University of Medical Sciences