An interventional study of Hand Sensorimotor Rehabilitation and Cognitive Remediation in PARKINSON DISEASE (Disorder), sponsored by Isfahan University of Medical Sciences. Enrolling by invitation at 1 site in Iran. Open to participants aged 45 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-11-04.
Sponsored by Isfahan University of Medical Sciences · Not applicable, Interventional, and Treatment
Evidence suggests the association between fine motor skills of the hand and cognitive function, as well as the positive effects of hand rehabilitation on hand function and the effectiveness of cognitive rehabilitation on cognitive functions in patients with Parkinson's disease (PD). In response to the question of whether there is a cause-and-effect relationship between fine manual skills and cognitive function, we designed the present randomized controlled trial to investigate the effectiveness of sensory-motor rehabilitation of the hand on cognitive functions compared to the effectiveness of cognitive rehabilitation on sensory-motor skills of the hand in patients with PD.
In this double-blinded, randomized controlled trial, a convenience sample including 48 people with PD will participate based on simple non-random sampling. The participants will be allocated randomly through stratified randomization to parallel groups of intervention (sensorimotor hand rehabilitation) and control (cognitive rehabilitation) with a 1:1 allocation ratio. The associate researcher responsible for assessing outcome measures and the statistician responsible for analyzing the data are blinded to the intervention protocol. The intervention protocol for the intervention group includes hand sensory-motor rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week, in addition to cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. The intervention protocol for the control group includes cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. All participants undergo three assessment sessions: the day before the intervention, the day after the intervention, and one month after the last intervention session. Data will be analyzed using SPSS version 22.0. The significance level will be set at 0.05.
4,573 studies on the registry are indexed under Parkinson Disease; 1,086 are open to participants now.
This study's planned enrollment of 48 is above the median of 40 across 3,353 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →Isfahan University of Medical Sciences is the lead sponsor of 150 studies on the registry; 8 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The intervention protocol includes hand sensory-motor rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week, in addition to cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week.
Other: Hand Sensorimotor Rehabilitation
The intervention protocol includes cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. The cognitive rehabilitation program will be conducted the same as the cognitive rehabilitation for the intervention group, which was explained in the previous section
Other: Hand Sensorimotor Rehabilitation · Other: Cognitive Remediation
10 one-and-a-half-hour sessions, 3 sessions per week
10 one-and-a-half-hour sessions, 3 sessions per week
Montreal Cognitive Assessment
To assess the general cognitive status of the participants. In the scoring of this test, a score of 26 and above indicates normal cognitive function, a score of 25 and below indicates mild cognitive impairment, and a score below 20 means severe cognitive impairment
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
Cambridge Neuropsychological Test Automated Battery - Reaction Time
To measure the speed of the participants' response to a visual target in which a predictable (simple reaction time) or unpredictable (choice reaction time) stimulus is presented. The approximate test time is 5 minutes. The response time latency is measured in milliseconds.
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
Cambridge Neuropsychological Test Automated Battery - Spatial Span Test
This test examines working and short-term memory. The participants are asked to tap on the squares on the monitor screen as they light up, in the order they appear. The approximate time to complete the test is 5 minutes
Time frame: - The day before the intervention - The day after the intervention - One month after ending intervention
Cambridge Neuropsychological Test Automated Battery - Match to Sample Visual Search Test
This test measures attention and visual search. In this test, a complex visual pattern is displayed in the middle of the monitor screen. After a short delay, a variable number of similar patterns are displayed in a circle around the edge of the monitor screen.
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
Cambridge Neuropsychological Test Automated Battery - Stop Signal Task
This test measures response inhibition. The test consists of two parts: in the first part, the participant is told to press the left button when they see an arrow pointing to the left direction and the right button when they see an arrow pointing right; In the second part, the participant is told to continue selecting buttons while they see the arrows, but if they hear an audible signal (beep), they must hold their response and not select the button
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
KING'S PD Pain Scale
this tool measures pain which is specifically designed for patients with PD.
Time frame: - The day before staring intervention - The day after ending intervention - one month after ending intervention
Box & Block Test
This test assesses hand fine motor skills by moving one-inch wooden cubes from one side of a 5.8 x 4.25 x 7.53 cm box to the other side.
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
The Purdue Pegboard Test
This test assesses fine motor skills and hand-eye coordination. The assembly subtest will considered in the present study.
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
Hand Dynamometer Hydraulic Jamar
This tool measures hand grip strength.
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
Pinch gauge
This tool measures fine fingertip grip strength
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
Semmes-Weinstein monofilaments
This test assesses the tactile pressure perception threshold
Time frame: - The day before staring intervention - The day after ending intervention - one month after ending intervention
The Michigan Hand Outcome Questionnaire
It measures the individual's own perspective on overall hand function
Time frame: - The day before staring intervention - The day after ending intervention - one month after ending intervention
Plan to share: No
No publications or documents are linked to this record.
Started Aug 2026 (actual). Primary completion is estimated for Jul 2027, 11 months after the start.
Of 1,291 non-industry interventional studies with no phase under Parkinson Disease, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 44. This study's planned 11 months is below that.
Counting every sponsor, half of 1,367 studies reached it within 25 months; a quarter within 11 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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