An interventional study of Hand Sensorimotor Rehabilitation and Cognitive Remediation in PARKINSON DISEASE (Disorder), sponsored by Isfahan University of Medical Sciences. Not yet recruiting. Open to participants aged 45 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-07-24.
Sponsored by Isfahan University of Medical Sciences · Not applicable, Interventional, and Treatment
Evidence suggests the association between fine motor skills of the hand and cognitive function, as well as the positive effects of hand rehabilitation on hand function and the effectiveness of cognitive rehabilitation on cognitive functions in patients with Parkinson's disease (PD). In response to the question of whether there is a cause-and-effect relationship between fine manual skills and cognitive function, we designed the present randomized controlled trial to investigate the effectiveness of sensory-motor rehabilitation of the hand on cognitive functions compared to the effectiveness of cognitive rehabilitation on sensory-motor skills of the hand in patients with PD.
In this double-blinded, randomized controlled trial, a convenience sample including 48 people with PD will participate based on simple non-random sampling. The participants will be allocated randomly through stratified randomization to parallel groups of intervention (sensorimotor hand rehabilitation) and control (cognitive rehabilitation) with a 1:1 allocation ratio. The associate researcher responsible for assessing outcome measures and the statistician responsible for analyzing the data are blinded to the intervention protocol. The intervention protocol for the intervention group includes hand sensory-motor rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week, in addition to cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. The intervention protocol for the control group includes cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. All participants undergo three assessment sessions: the day before the intervention, the day after the intervention, and one month after the last intervention session. Data will be analyzed using SPSS version 22.0. The significance level will be set at 0.05.
Exclusion Criteria:
The intervention protocol includes hand sensory-motor rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week, in addition to cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week.
Other: Hand Sensorimotor Rehabilitation
The intervention protocol includes cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. The cognitive rehabilitation program will be conducted the same as the cognitive rehabilitation for the intervention group, which was explained in the previous section
Other: Hand Sensorimotor Rehabilitation · Other: Cognitive Remediation
10 one-and-a-half-hour sessions, 3 sessions per week
10 one-and-a-half-hour sessions, 3 sessions per week
Montreal Cognitive Assessment
To assess the general cognitive status of the participants. In the scoring of this test, a score of 26 and above indicates normal cognitive function, a score of 25 and below indicates mild cognitive impairment, and a score below 20 means severe cognitive impairment
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
Cambridge Neuropsychological Test Automated Battery - Reaction Time
To measure the speed of the participants' response to a visual target in which a predictable (simple reaction time) or unpredictable (choice reaction time) stimulus is presented. The approximate test time is 5 minutes. The response time latency is measured in milliseconds.
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
Cambridge Neuropsychological Test Automated Battery - Spatial Span Test
This test examines working and short-term memory. The participants are asked to tap on the squares on the monitor screen as they light up, in the order they appear. The approximate time to complete the test is 5 minutes
Time frame: - The day before the intervention - The day after the intervention - One month after ending intervention
Cambridge Neuropsychological Test Automated Battery - Match to Sample Visual Search Test
This test measures attention and visual search. In this test, a complex visual pattern is displayed in the middle of the monitor screen. After a short delay, a variable number of similar patterns are displayed in a circle around the edge of the monitor screen.
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
Cambridge Neuropsychological Test Automated Battery - Stop Signal Task
This test measures response inhibition. The test consists of two parts: in the first part, the participant is told to press the left button when they see an arrow pointing to the left direction and the right button when they see an arrow pointing right; In the second part, the participant is told to continue selecting buttons while they see the arrows, but if they hear an audible signal (beep), they must hold their response and not select the button
Time frame: - The day before the intervention - The day after the intervention - One month after the last intervention session
KING'S PD Pain Scale
this tool measures pain which is specifically designed for patients with PD.
Time frame: - The day before staring intervention - The day after ending intervention - one month after ending intervention
Box & Block Test
This test assesses hand fine motor skills by moving one-inch wooden cubes from one side of a 5.8 x 4.25 x 7.53 cm box to the other side.
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
The Purdue Pegboard Test
This test assesses fine motor skills and hand-eye coordination. The assembly subtest will considered in the present study.
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
Hand Dynamometer Hydraulic Jamar
This tool measures hand grip strength.
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
Pinch gauge
This tool measures fine fingertip grip strength
Time frame: - The day before starting intervention - The day after ending intervention - One month after ending intervention
Semmes-Weinstein monofilaments
This test assesses the tactile pressure perception threshold
Time frame: - The day before staring intervention - The day after ending intervention - one month after ending intervention
The Michigan Hand Outcome Questionnaire
It measures the individual's own perspective on overall hand function
Time frame: - The day before staring intervention - The day after ending intervention - one month after ending intervention
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Plan to share: No
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Isfahan University of Medical Sciences