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CompletedNCT01292343Updated Oct 28, 2015

Triclosan Toothpaste and Third Molar Surgery

An interventional study of Colgate Total Toothpaste and Colgate Regular Toothpaste in Dry Socket and Wound Infection, sponsored by University of Rochester. Completed at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-10-28.

Sponsored by University of Rochester · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
141
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
All
01

Study summary

Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

Read the detailed description

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

02

Conditions studied

  • Dry Socket
  • Wound Infection

Keywords

  • third molars
  • triclosan
  • toothpaste
  • dry socket
  • wound infection
03

In context

Dry Socket

46 studies on the registry are indexed under Dry Socket; 10 are open to participants now.

This study's enrollment of 141 is above the median of 60 across 41 interventional studies indexed under Dry Socket.

Browse Dry Socket studies →

Lead sponsor

University of Rochester is the lead sponsor of 729 studies on the registry; 116 are open to participants now.

Of its 56 completed or terminated interventional studies of FDA-regulated products, 44 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • must include at least one mandibular third molar with partial or full bony impaction
  • no sign of active pericoronal (around the crown) infections
  • must have not taken antibiotics for any reason in the past 30 days
  • must be healthy and between 18 and 35 years of age
  • must be able to read and sign an

Exclusion criteria

Exclusion Criteria:

  • Subjects with systemic diseases and pregnant or lactating women
  • Subjects with advanced periodontal diseases or having two or more untreated caries lesions
  • Subjects who cannot read and sign an
  • Subjects with signs of pericoronal infections
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
141 participants (actual)

Interventions

  • OtherColgate Total Toothpaste

    Toothbrushing with Colgate Total Toothpaste

    Also known as: triclosan, dentifrice

  • OtherColgate Regular Toothpaste

    Toothbrushing with Colgate regular toothpaste

    Also known as: fluoride, dentifrice

06

What researchers measure

Primary outcomes

  1. dry socket

    Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction

    Time frame: 3 to 7 days

Secondary outcomes

  1. wound infection

    Development of tooth extraction wound infection 3 to 7 days after extraction

    Time frame: 3 to 7 days

07

Study locations

1 site
  • University of Rochester Eastman Dental Center
    Rochester, New York 14620, United States
08

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Feb 2008, a primary completion of Feb 2013 and a completion of Feb 2013. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 4, 2011
First posted
Feb 9, 2011
Start
Feb 2008
Primary completionActual
Feb 2013
CompletionActual
Feb 2013
Last update
Oct 28, 2015
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Oct 28, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01292343
Responsible party
Yanfang Ren (Professor, University of Rochester) — Principal investigator
First posted
Feb 9, 2011
Start date
Feb 2008
Primary completion
Feb 2013
Completion
Feb 2013
Last update
Oct 28, 2015

Study contacts

Yanfang Ren, DDS, MPH
principal investigator · University of Rochester Eastman Dental Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2015. You cannot join it, but the record below documents what was studied.

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