An observational study in Heat Stroke and Healthy, sponsored by Sheba Medical Center. Completed at 1 site in Israel. Open to male participants aged 18 Years to 28 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-12-19.
Sponsored by Sheba Medical Center · Observational
Today, the level of tolerance to heat is based on physiological strain indices, with no correlates to any relevant biomarker. We hypothesize that oxidative stress (OS) and the formation of reactive oxygen and nitrogen species (ROS, RNS), which are part of the underling pathophysiology related to hyperthermia, can be used to identify tolerance/intolerance to heat. The aim of the present project is to develop a simple assay, based on specific designed sensitive biomarkers of OS that can be detected in a small blood sample, and to possibly correlate each individual's state of tolerance to heat to the level of OS. These biomarkers specially designed and synthesized to form a novel probe (not present as such in biological organs). The method will be based on the incubation of the suggested biomarkers with the patient's blood sample and the measurement of the level and type of oxidative alteration of the markers. For this goal, post heat stroke patients, with different levels of tolerance to heat and subjects during a process of acclimation to heat will be studied. Such a method will add to our ability to better determine the level of tolerance to heat and not rely only on the measurements of temperature and heart rate during an exercise-heat stress.
21 studies on the registry are indexed under Heat Stroke; 10 are open to participants now.
Browse Heat Stroke studies →Sheba Medical Center is the lead sponsor of 678 studies on the registry; 63 are open to participants now.
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young (18-28 years old) post heat stroke subjects, and matched healthy controls
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for study group: post heat stroke subjects. for control group: healthy subjects matched by age to study group
Exclusion Criteria:
for control group: any prior heat illness, Diabetes, heart failure, high blood pressure (SBP >140mmHg), any febrile illness within the last two weeks prior to testing.
for study group: Diabetes, heart failure, high blood pressure (SBP >140mmHg), any febrile illness within the last two weeks prior to testing
Other: heat tolerance test (HTT)
Other: heat tolerance test (HTT)
Other: heat tolerance test (HTT)
An exercise-heat test,which consists of 120 min exposure to walking on a treadmill (5km/h; 2% grade) under conditions of 40oC and 50% rh.
Also known as: heat strain
This study is completed, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.
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