ClinicalTrials.gg
CompletedNCT01236729Updated Oct 18, 2023

Disability and Self-rated Health Following Primary Knee Replacement

An observational study in Osteoarthritis and Knee Replacement, sponsored by Coxa, Hospital for Joint Replacement. Completed at 1 site in Finland. Open to participants aged 75 Years and older. Per ClinicalTrials.gov, last updated 2023-10-18.

Sponsored by Coxa, Hospital for Joint Replacement · Observational

Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
460
Ages
75 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 37 studies in Osteoarthritis with a site in Finland — 5 open to participants now, 10 under way, none of them phase 3. Osteoarthritis · Finland.

Enrollment
2nd of 12
460 · median 138
Started
2009
with 4 others
Observational
12 of 37
2 open now
Registered
10th of 37
by date
Lead sponsor
3 of 37
Coxa, Hospital for Joint Replacement

Among the 37 studies in Osteoarthritis with a site in Finland, this one is the 2nd largest by enrollment of the 12 observational ones that give a count, is one of 5 that started in 2009, is one of 12 observational ones, and was the 10th registered.

Osteoarthritis

2,974 studies on the registry are indexed under Osteoarthritis; 435 are open to participants now.

Browse Osteoarthritis studies →

Open to participants now

5 of the 37 studies in Osteoarthritis with a site in Finland are open now. Recruiting first, the newest first:

All 5 open studies →

A study can be open while its sites in Finland have not opened yet or have stopped. Only those recruiting at a site in Finland →

Who these studies take

Of the 285 Osteoarthritis studies recruiting now, 157 (55%) set no upper age limit and 71 (25%) stop at 75 or younger; 22 take children under 18; 30 take healthy volunteers.

This study: 75 Years and older · all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

Was this useful?
Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 37 studies in Osteoarthritis with a site in Finland, or all of them as a file.
02

Study summary

Knee replacement is an effective treatment in late-stage osteoarthritis. It reduces pain and improves quality of life. There is, however, limited data concerning its results in older people and on its effect on how patients survive in regular activities of daily living (ADL), such as bathing and shopping. In this study, the results of knee replacement are evaluated from the point of view of disability in everyday activities and self-rated health. Moreover, association with ADL performance and clinical knee scores and severity of osteoarthritis are assessed.

Read the detailed description

This is a cross-sectional study with a 12 month follow-up for recruited patients. Most data are gathered by a postal questionnaire.

03

Conditions studied

  • Osteoarthritis
  • Knee Replacement

Browse trials for

Keywords

  • knee replacement
  • disability
  • older people
04

Who can participate

Ages eligible
75 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients refererred to or operated on with primary knee replacement in a population-based tertiary care hospital

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • age 75 years or more at the time of operation
  • diagnosis of knee osteoarthritis
  • scheduled for or operated on with primary knee replacement

Exclusion criteria

Exclusion Criteria:

  • died during the follow-up
  • inflammatory arthritides
05

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
460 participants (actual)

Groups and cohorts

  • Knee replacement recipients

    Patients (aged 75 years or over) with late-stage arthritis who have undergone or are undergoing primary knee replacement

06

What researchers measure

Primary outcomes

  1. Disability in activities of daily living

    Time frame: Baseline (recruitment) and at 12 months

Secondary outcomes

  1. Overall self-rated health

    Time frame: Baseline (recruitment) and at 12 months

  2. Health-related quality of life (WOMAC)

    For patients recruited in 2011-2012.

    Time frame: Baseline and 12 months postoperatively

07

Study locations

1 site
  • Coxa, Hospital for Joint Replacement
    Tampere, 33101, Finland
08

References and documents

Publications

  • Limnell K, Jamsen E, Huhtala H, Jantti P, Puolakka T, Jylha M. Functional ability, mobility, and pain before and after knee replacement in patients aged 75 and older: a cross-sectional study. Aging Clin Exp Res. 2012 Dec;24(6):699-706. doi: 10.3275/8718. Epub 2012 Nov 12. PubMed 23147559 ↗
  • Vekama L, Puolakka T, Honkasalo M, Huhtala H, Moilanen T, Jamsen E. Functional gain following knee replacement in patients aged 75 and older: a prospective follow-up study. Aging Clin Exp Res. 2015 Dec;27(6):865-76. doi: 10.1007/s40520-015-0348-x. Epub 2015 Mar 24. PubMed 25800623 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Dec 2009, a primary completion of Nov 2013 and a completion of Dec 2015. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 22, 2009
First posted
Nov 9, 2010
Start
Dec 2009
Primary completionActual
Nov 30, 2013
CompletionActual
Dec 31, 2015
Last update
Oct 18, 2023
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Oct 18, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01236729
Lead sponsor
Coxa, Hospital for Joint Replacement
Collaborators
Tampere University
Responsible party
Esa Jamsen (MD, PhD, Researcher, Coxa, Hospital for Joint Replacement) — Principal investigator
First posted
Nov 9, 2010
Start date
Dec 2009
Primary completion
Nov 30, 2013
Completion
Dec 31, 2015
Last update
Oct 18, 2023

Study contacts

Esa Jämsen, MD, PhD
study director · Coxa, Hospital for Joint Replacement

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion