An observational study in Hyperparathyroidism, sponsored by Hadassah Medical Organization. Status unknown at 1 site in Israel. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2010-10-15.
Sponsored by Hadassah Medical Organization · Observational
The purpose of the study is to determine a possible input of C11-Choline PET/CT in identification and localization of a parathyroid adenoma (PTA).
Preoperative localization of a PTA has been previously documented in multiple series, and is usually based on scintigraphy and on US.
Currently, the conventional technique for localization of a PTA is a dual-isotope scan with Tc99m-MIBI and Tc99m pertechnetate. This study is acquired over at least 3 hours, includes two i.v. injections and the patient has to stay 15-30 min per acquisition under the camera.
In addition, there is no anatomical imaging and further correlation with US is usually recommended.
In contrast, PET/CT study with C11-Choline takes as long as 10 min., includes one injection, and provides data of higher resolution of functional (PET) and anatomical imaging (CT).
Furthermore, dosimetric data shows that the total effective dose from Tc99mMIBI and Tc99m pertechnetate injection is (without CT): 0.5957 rem; and from C11-Choline injection and CT of a chest is: 0.3128 - 0.8628rem.
305 studies on the registry are indexed under Hyperparathyroidism; 23 are open to participants now.
This study's planned enrollment of 100 is close to the median of 100 across 88 observational studies indexed under Hyperparathyroidism.
Browse Hyperparathyroidism studies →Hadassah Medical Organization is the lead sponsor of 659 studies on the registry; 54 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with elevated PTH in search of a PTA
Inclusion Criteria:
Patients with hyperparathyroidism, prior to surgery.
Procedure: C11-Choline PET/CT
Improved localization of a parathyroid adenoma
Facilitation of detection of the parathyroid adenoma at surgery
This study is status unknown, as verified in Oct 2010. You cannot join it, but the record below documents what was studied.
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Hadassah Medical Organization