An interventional study of Glucose and Fructose in Metabolic Syndrome, Insulin Resistance and Dyslipidemia, sponsored by University of California, Davis. Completed at 1 site in United States. Open to participants aged 40 Years to 72 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-05-30.
Sponsored by University of California, Davis · Not applicable, Interventional, and Basic science
The purpose of this study is compare the effects of consuming glucose- and fructose-sweetened beverages on appetite, body weight, body fat, and the amount of energy the body burns as well as effects on blood pressure, hormones, blood triglycerides and cholesterol, and the body's sensitivity to the insulin.
The study is designed as a prospective, blinded diet intervention study during which the participants consume either fructose- or glucose-sweetened beverages (25% of energy) with meals. Experimental procedures, including 24-hour serial blood sampling, 26-h stable isotoped infusions, post-heparin blood collection, gluteal biopsies, metabolic rate monitoring, computed tomography scans of the abdomen, and Oral Glucose Tolerance and Disposal Tests, are performed during baseline and at the end of a 10-week intervention period at the UC Davis School of Medicine/Sacramento Veterans Affairs Medical Center Clinical Research Center (CCRC). During the 2-week inpatient baseline period, subjects are served energy balanced diets containing 15% of energy as protein, 30% as fat, and 55% as complex carbohydrate. Following the baseline period, the subjects reside at home for 8 weeks and consume their usual ad libitum diet along with 25% of energy requirements as fructose- or glucose-sweetened beverages. Subjects then return to the CCRC for the 2-week inpatient intervention period at the end of the study and are served energy-balanced diets containing 15% of energy as protein, 30% as fat, 30% as complex carbohydrate and 25% of energy as fructose- or glucose-sweetened beverage.
2,011 studies on the registry are indexed under Metabolic Syndrome; 334 are open to participants now.
This study's enrollment of 32 is below the median of 60 across 1,494 interventional studies indexed under Metabolic Syndrome.
Browse Metabolic Syndrome studies →University of California, Davis is the lead sponsor of 809 studies on the registry; 145 are open to participants now.
Of its 67 completed or terminated interventional studies of FDA-regulated products, 43 (64%) have results posted.
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Exclusion Criteria:
Other: Glucose
Other: Fructose
25% dose at 8-week intervention assigned to subjects.
Also known as: sugar
25% dose at 8-week intervention assigned to subjects.
Also known as: sugar
24-hour triglyceride area under the curve
32 serial blood samples are collected over a 24 hour period.
Time frame: Baseline and 8-week intervention
Insulin sensitivity index
Insulin sensitivity is assessed using the deuterated glucose disposal method.
Time frame: Baseline and 8-week intervention
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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