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RecruitingNCT03054584Updated Sep 17, 2026

Genetic Basis of Melanocytic Nevi

An observational study in Melanocytic Nevi, sponsored by University of California, Davis. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-17.

Sponsored by University of California, Davis · Observational

From the registry’s dates

  • Started Jun 2017; still recruiting 9 years 4 months later.
Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
50
Ages
18 Years and older
Sex
All
01

Study summary

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.

Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:

  1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.
  2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
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Conditions studied

  • Melanocytic Nevi

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03

In context

Nevus, Pigmented

19 studies on the registry are indexed under Nevus, Pigmented; 6 are open to participants now.

This study's planned enrollment of 50 is close to the median of 50 across 11 observational studies indexed under Nevus, Pigmented.

Browse Nevus, Pigmented studies →

Lead sponsor

University of California, Davis is the lead sponsor of 809 studies on the registry; 142 are open to participants now.

Of its 67 completed or terminated interventional studies of FDA-regulated products, 43 (64%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Subjects seen in UC Davis dermatology clinic diagnosed as having melanocytic nevi will be recruited from the clinic during their routine visit. Subjects identified in clinic will be approached after their clinic visit.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male or female subjects that are 18 years or older
  • Subjects with melanocytic nevi\

Exclusion criteria

Exclusion criteria:

  • Patients less than 18 years of age
  • Patients without melanocytic nevi
  • Patients with a bleeding disorder or are taking anticoagulation medication
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Study design

Observational model
Other
Time perspective
Prospective
Enrollment
50 participants (estimated)
Patient registry
No

Interventions

  • OtherCollecting Nevi

    Will be collecting Nevi and completing a DNA analysis, no intervention will be made.

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What researchers measure

Primary outcomes

  1. Genome Wide Mutation Analysis

    Will be performing genome wide mutation analysis to quantify the number of mutations.

    Time frame: Feb 2017 - December 2018

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 17, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03054584
Responsible party
Sponsor
First posted
Feb 15, 2017
Start date
Jun 26, 2017
Primary completion
Jun 2028 (estimated)
Completion
Jun 2028 (estimated)
Last update
Sep 17, 2026

Study contacts

Maija Kiuru, MD
Contact
mkiuru@ucdavis.edu
916-734-0591
John Robb
Contact
jmrobb@ucdavis.edu
916-551-2636

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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