CClinicalTrials.gg
CompletedNCT01122056Updated Mar 3, 2017

Effect of Aerobic Exercise on Side Effects of Disease Modifying Therapy With Subcutaneous Interferon-b1b in Patients With Multiple Sclerosis

An interventional study of Physical exercise training in Multiple Sclerosis, sponsored by University of British Columbia. Completed at 1 site in Canada. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2017-03-03.

Sponsored by University of British Columbia · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
128
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The purpose of this study is to investigate the effects and tolerability of exercise on side effects of injectable disease modifying treatments in multiple sclerosis. The investigators main hypothesis is that controlled exercise is safe and can be well tolerated in patients with multiple sclerosis and it can improve disease modifying treatment related side effects such as fatigue.

Read the detailed description

Patient compliance with disease modifying treatment largely depends on relatively common side effects of such treatments such as fatigue. Regular exercise can potentially improve these side effects. However, Safety and effects of exercise has not been studied in patients with multiple sclerosis. Our main aim is to study the safety, tolerability and effects of exercise on side effects of subcutaneous interferon-b1b in patients with Multiple Sclerosis.

02

Conditions studied

  • Multiple Sclerosis

Keywords

  • Multiple Sclerosis
  • b1b-interferon
  • Fatigue
  • Exercise
03

In context

Multiple Sclerosis

3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.

This study's planned enrollment of 128 is above the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.

Browse Multiple Sclerosis studies →

Lead sponsor

University of British Columbia is the lead sponsor of 1,309 studies on the registry; 253 are open to participants now.

Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria:

  • Recent diagnosis of relapsing remitting multiple sclerosis on treatment with b1b-interferon disease modifying treatment
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Single group
Masking
Single (Participant)
Enrollment
128 participants (estimated)

Study arms

  • Active comparator
    A = Active group

    Patients will receive interactive exercise training session from an experienced multiple sclerosis

    Other: Physical exercise training

  • No intervention
    B = Control group (Placebo Comparator)

    Patients will receive general advice about benefits/side effects of physical activity in multiple sclerosis.

Interventions

  • OtherPhysical exercise training

    Two 2-hours long interactive training to perform safe and efficient aerobic exercise for patients with multiple sclerosis

    Also known as: Betaseron b1b-interferon, Aerobic exercise

06

What researchers measure

Primary outcomes

  1. Multiple Sclerosis Fatigue

  2. Quality of Life

  3. Injection site visual analog scale (0-10)

07

Study locations

1 site
  • Vancouver Coastal Health: University of British Columbia Hospital
    Vancouver, British Columbia, Canada
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 3, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01122056
Lead sponsor
University of British Columbia
Collaborators
Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma
Responsible party
Sponsor
First posted
May 12, 2010
Start date
May 2010
Primary completion
Jun 1, 2012
Completion
Jun 1, 2012
Last update
Mar 3, 2017

Study contacts

Laura Boyd
study director · University of British Columbia
Kristen Campbell
study director · University of British Columbia
Saul Isserow
study director · University of British Columbia

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion