A Phase 4 interventional study of Pro-biotics and Oligosaccharide in Peritonitis and Malnutrition, sponsored by National Cheng-Kung University Hospital. Status unknown at 1 site in Taiwan. Open to participants aged 16 Years to 75 Years. Per ClinicalTrials.gov, last updated 2010-02-26.
Sponsored by National Cheng-Kung University Hospital · Phase 4, Interventional, and Treatment
The purpose of this study is to determine whether probiotics can improve the nutrition status and prevent peritonitis in the chronic peritoneal dialysis patients.
Peritoneal dialysis was one of therapies for uremia patient. However, peritoneal dialysis related peritonitis was a major complication for these patients. Severe and prolong peritonitis may led to membrane failure and drop out of peritoneal dialysis. Among the pathogens, G(+) bacteria came from skin surface and G(-) bacteria came from gastrointestinal tract. The later might be related to the pathogens in the gastrointestinal tract, and led to peritonitis if constipation or diarrhea developed. In addition, intestinal pathogens may be related to chronic inflammation in uremia patients. There was a MIA syndrome (malnutrition, inflammation and atherosclerosis) noted before, and chronic inflammation may be related to malnutrition. Today, we know that nutrition status and inflammation marker (CRP) may be associated with patients' outcome. Many gastrointestinal syndromes such as constipation suffer our patients. The dialysate in the abdominal cavity may further exacerbate the appetite. The probiotics was though to improve the pathogens in intestinal tract, improve gastrointestinal function. We want to decrease the incidence of peritonitis by using the probiotics. In addition, the improvement in gastrointestinal function can increase the nutrition status.
185 studies on the registry are indexed under Peritonitis; 25 are open to participants now.
This study's planned enrollment of 100 is close to the median of 95 across 118 interventional studies indexed under Peritonitis.
Browse Peritonitis studies →National Cheng-Kung University Hospital is the lead sponsor of 268 studies on the registry; 68 are open to participants now.
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Exclusion Criteria:
probiotics treatment
Drug: Pro-biotics
Dietary Supplement: Oligosaccharide
Pro-biotics and placebo one pack per day is given to the two group. And then evaluate the peritonitis rate and nutrition status.
oligosaccharide one pack per day
peritonitis rate
Time frame: one year
nutrition status
Time frame: 3, 6, 9, 12 months
This study is status unknown, as verified in Feb 2010. You cannot join it, but the record below documents what was studied.
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National Cheng-Kung University Hospital