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CompletedNCT01074827Updated Jul 8, 2015

Improving Gait in Multiple Sclerosis (MS) - Strength Training or Treadmill Walking?

An interventional study of Strength training and treadmill training in Multiple Sclerosis, sponsored by St. Olavs Hospital. Completed at 1 site in Norway. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-07-08.

Sponsored by St. Olavs Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
28
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The objective of this study is to evaluate the effect of strength training for the lower extremities and treadmill training on walking ability in persons with Multiple Sclerosis. The study is a randomized control trial with two groups and the intervention is 8 weeks of intensive strength training or treadmill walking. Primary outcome measure is walking ability, secondary outcome measures are balance, work economy and strength.

02

Conditions studied

  • Multiple Sclerosis

Keywords

  • Multiple Sclerosis
  • Walking ability
  • Strength
  • Balance
  • Treadmill walking
03

In context

Multiple Sclerosis

3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.

This study's enrollment of 28 is below the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.

Browse Multiple Sclerosis studies →

Lead sponsor

St. Olavs Hospital is the lead sponsor of 165 studies on the registry; 30 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosed with Multiple Sclerosis,classified as relapsing remitting,or primary/secondary progressive
  • Expanded Disability Status Scale (EDSS)score of ≤ 6
  • Reduced walking ability (subjectively experienced)

Exclusion criteria

Exclusion Criteria:

  • persons with a level of ataxia, clinically assessed, that would affect their ability to perform the training.
  • spasticity requiring stretching og treatment with baclofen.
  • Other, not MS-related, conditions affecting walking ability.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
28 participants (actual)

Study arms

  • Experimental
    Treadmill group

    Specific gait training on treadmill

    Other: Strength training and treadmill training

  • Experimental
    Strength training group

    Eight weeks of intensive strength training

    Other: Strength training and treadmill training

Interventions

  • OtherStrength training and treadmill training

    Eight weeks of intensive strength training or treadmill training

06

What researchers measure

Primary outcomes

  1. Walking ability

    Time frame: 8 weeks

Secondary outcomes

  1. Strength

    Time frame: 8 weeks

  2. Work economy O2

    Time frame: 8 weeks

  3. Balance

    Time frame: 8 weeks

07

Study locations

1 site
  • St. Olavs Hospital
    Trondheim, 7006, Norway
08

References and documents

Publications

  • Braendvik SM, Koret T, Helbostad JL, Loras H, Brathen G, Hovdal HO, Aamot IL. Treadmill Training or Progressive Strength Training to Improve Walking in People with Multiple Sclerosis? A Randomized Parallel Group Trial. Physiother Res Int. 2016 Dec;21(4):228-236. doi: 10.1002/pri.1636. Epub 2015 Jun 25. PubMed 26110230 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 8, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01074827
Lead sponsor
St. Olavs Hospital
Collaborators
Norwegian University of Science and Technology, Helse Midt-Norge
Responsible party
Sponsor
First posted
Feb 24, 2010
Start date
Mar 2010
Primary completion
Apr 2011
Completion
Apr 2011
Last update
Jul 8, 2015

Study contacts

Siri M, Brændvik
study chair · St. Olavs Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.

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