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Status unknownNCT01024985Updated Jun 28, 2010

Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct

An observational study in Multiple Sclerosis and Neuromyelitis Optica, sponsored by University of Sao Paulo. Status unknown at 1 site in Brazil. Open to participants aged 15 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-06-28.

Sponsored by University of Sao Paulo · Observational

The sponsor has not verified this record recently (last verified Jun 2010), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
40
Ages
15 Years to 60 Years
Sex
All
01

Study summary

The purpose of this study is to determine the ability of STRATUS OCT and high resolution OCT to detect and to quantify the neural loss in multiple sclerosis and neuromyelitis optica and its subtypes.

02

Conditions studied

  • Multiple Sclerosis
  • Neuromyelitis Optica

Keywords

  • optic neuritis
  • longitudinally extensive transverse myelitis
  • retinal nerve fiber layer
  • macular thickness
03

In context

Multiple Sclerosis

3,525 studies on the registry are indexed under Multiple Sclerosis; 668 are open to participants now.

This study's planned enrollment of 40 is below the median of 100 across 1,034 observational studies indexed under Multiple Sclerosis.

Browse Multiple Sclerosis studies →

Lead sponsor

University of Sao Paulo is the lead sponsor of 1,032 studies on the registry; 93 are open to participants now.

Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
15 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

patients of ophthalmology and/or neurology departments of hopital das clinicas of medical school of university of sao paulo

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • clinical diagnosis of multiple sclerosis or neuromyelitis optica
  • age between 15 and 60 years
  • BCVA better than 20/400
  • no optic neuritis crisis in the last 6 months

Exclusion criteria

Exclusion Criteria:

  • diagnosis of glaucoma, opacities or disc anomalies
  • diagnosis of macular disease
  • disc swelling at fundoscopy
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
40 participants (estimated)

Groups and cohorts

  • multiple sclerosis
  • neuromyelitis optica
  • controls
06

Study locations

1 of 1 sites recruiting
  • Hospital Das Clinicas Medical School of University of Sao Paulo
    São Paulo, São Paulo 05403-000, Brazil
    • heloisa helena, nurse · Contact · 55 11 3069 6596
    • danilo B fernandes, md · Sub investigator
    • kenzo hokazono, md · Sub investigator
    Recruiting
07

References and documents

Publications

  • Hokazono K, Raza AS, Oyamada MK, Hood DC, Monteiro ML. Pattern electroretinogram in neuromyelitis optica and multiple sclerosis with or without optic neuritis and its correlation with FD-OCT and perimetry. Doc Ophthalmol. 2013 Dec;127(3):201-15. doi: 10.1007/s10633-013-9401-2. Epub 2013 Jul 30. PubMed 23892551 ↗
  • Monteiro ML, Fernandes DB, Apostolos-Pereira SL, Callegaro D. Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Jun 26;53(7):3959-66. doi: 10.1167/iovs.11-9324. PubMed 22589446 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 28, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01024985
First posted
Dec 3, 2009
Start date
Sep 2009
Primary completion
Dec 2010 (estimated)
Completion
Dec 2011 (estimated)
Last update
Jun 28, 2010

Study contacts

mario luiz r monteiro, phd
Contact
mlrmonteiro@terra.com.br
55 11 30697871

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2010. You cannot join it, but the record below documents what was studied.

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