An observational study in Diastolic Dysfunction, Coronary Artery Disease and General Anesthesia, sponsored by Washington University School of Medicine. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2010-11-05.
Sponsored by Washington University School of Medicine · Observational
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
Diastolic heart dysfunction is a significant cause of cardiovascular morbidity and is the cause of symptomatic heart failure in approximately one half of patients who are admitted to hospitals with heart failure symptoms. However, diastolic heart function remains difficult to measure objectively without cardiac catheterization. Diastolic heart dysfunction is also common among patients undergoing coronary bypass grafting (CABG) surgery. Despite the ubiquitous use of inhaled volatile drugs to maintain anesthesia in these patients, their effects upon diastolic heart function remain unclear.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's enrollment of 21 is below the median of 336 across 1,947 observational studies indexed under Coronary Artery Disease.
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Patients undergoing non-emergent coronary artery bypass grafting surgery at a tertiary care center
Exclusion Criteria:
Diastolic efficiency index (derived from the parameterized analysis of transmitral early filling Doppler using the paradigm of the ventricle as a damped harmonic oscillator)
Time frame: Following induction of volatile anesthesia
Diastolic efficiency index (derived from the parameterized analysis of transmitral early filling Doppler using the paradigm of the ventricle as a damped harmonic oscillator)
Time frame: Following the onset of controlled ventilation
This study is completed, as verified in Nov 2010. You cannot join it, but the record below documents what was studied.
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Washington University School of Medicine