CClinicalTrials.gg
Sign In
CompletedNCT00863564Updated Nov 10, 2009

Acute Effects of Dietary Proteins on Postprandial Lipemia, Incretin Responses and Subclinical Inflammation in Obese Subjects

An interventional study of Caseine and Cod in Obesity, Postprandial Lipemia and Atherosclerosis, sponsored by Aarhus University Hospital. Completed at 1 site in Denmark. Open to participants aged 40 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-11-10.

Sponsored by Aarhus University Hospital · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Randomized
Ages
40 Years to 75 Years
Sex
All
01

Study summary

The purpose of this study is to determine the effects of dietary protein on blood lipids and gut hormones after a fat-rich meal.

Hypothesis: Certain dietary proteins reduce the amount of fat circulating in the blood stream following a fat rich meal. The effect is dependant of both the quality and the quantity of protein ingested.

02

Conditions studied

  • Obesity
  • Postprandial Lipemia
  • Atherosclerosis
  • Inflammation
  • Postprandial Incretins

Keywords

  • Postprandial Period
  • Postprandial Lipaemia
  • Incretins
  • Subclinical Inflammation
  • Obesity
  • Atherosclerosis
  • Triglyceride
  • Lipoproteins
  • Postprandial inflammation
03

In context

Atherosclerosis

1,567 studies on the registry are indexed under Atherosclerosis; 264 are open to participants now.

This study's planned enrollment of 12 is below the median of 106 across 882 interventional studies indexed under Atherosclerosis.

Browse Atherosclerosis studies →

Lead sponsor

Aarhus University Hospital is the lead sponsor of 289 studies on the registry; 79 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • BMI > 30 kg/m2 \& \< 45 kg/m2

Exclusion criteria

Exclusion Criteria:

  • Diabetes
  • Lipid lowering drugs
  • Liver-, Kidney- and/or Heart Disease
  • Serious Hypertension (160/110)
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
12 participants (estimated)

Study arms

  • Active comparator
    Whey Isolate

    Dietary Supplement: Whey Isolate

  • Active comparator
    Caseine

    Dietary Supplement: Caseine

  • Active comparator
    Cod

    Dietary Supplement: Cod

  • Active comparator
    Gluten

    Dietary Supplement: Gluten

Interventions

  • Dietary supplementCaseine
  • Dietary supplementCod
  • Dietary supplementGluten
  • Dietary supplementWhey Isolate
06

What researchers measure

Primary outcomes

  1. Triglyceride

    Time frame: 0h- 2h- 4h- 6h- 8h postprandial

Secondary outcomes

  1. Incretins

    Time frame: 0h -1h -2h -4h -6h -8h Postprandial

  2. Inflammatory markers

    Time frame: 0h- 1h- 2h- 4h- 6h- 8h postprandial

07

Study locations

1 site
  • Department of Clinical Nutrion
    Aarhus, 8000, Denmark
08

References and documents

Publications

  • Holmer-Jensen J, Karhu T, Mortensen LS, Pedersen SB, Herzig KH, Hermansen K. Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects. Nutr J. 2011 Oct 19;10:115. doi: 10.1186/1475-2891-10-115. PubMed 22011432 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 10, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00863564
Lead sponsor
Aarhus University Hospital
Collaborators
The Danish Obesity Research Centre, Nordic Centre of Excellence
First posted
Mar 18, 2009
Start date
Mar 2009
Primary completion
Oct 2009
Completion
Oct 2009
Last update
Nov 10, 2009

Study contacts

K Hermansen, Professor, MD
principal investigator · Department of Endocrinology and Metabolism, Aarhus University Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2009. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Atherosclerosis→

Other studies from this sponsor

Aarhus University Hospital

Start the discussion