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TerminatedNCT00799942Updated Jul 1, 2010

Open-lable Extension Study on Safety and Efficacy of Neramexane to Treat Congenital and Acquired Nystagmus

A Phase 2 interventional study of Neramexane mesylate in Nystagmus, Congenital, Nystagmus, Acquired and Multiple Sclerosis, sponsored by Merz Pharmaceuticals GmbH. Terminated at 1 site in United Kingdom. Open to participants aged 18 Years to 81 Years. Per ClinicalTrials.gov, last updated 2010-07-01.

Sponsored by Merz Pharmaceuticals GmbH (part of Merz Pharma) · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
48
Allocation
Not applicable
Ages
18 Years to 81 Years
Sex
All
01

Study summary

The purpose of this study is to investigate the long-term safety, tolerability and efficacy of neramexane mesylate in the treatment of congenital idiopathic nystagmus (CIN). In addition, a subgroup of multiple sclerosis (MS) patients suffering from acquired nystagmus will be included.

02

Conditions studied

  • Nystagmus, Congenital
  • Nystagmus, Acquired
  • Multiple Sclerosis

Keywords

  • Nystagmus, congenital idiopathic
03

In context

Nystagmus, Pathologic

27 studies on the registry are indexed under Nystagmus, Pathologic; 3 are open to participants now.

This study's planned enrollment of 48 is close to the median of 48 across 17 interventional studies indexed under Nystagmus, Pathologic.

Browse Nystagmus, Pathologic studies →

Lead sponsor

Merz Pharmaceuticals GmbH is the lead sponsor of 61 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 81 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patients who has succesfully completed the lead-in study MRZ 92579-0707/1

Exclusion criteria

Exclusion Criteria:

  • Occurence of any major treatment-emergent adverse event or condition during the previous protocol (MRZ 92579-0707/1)
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
48 participants (estimated)

Interventions

  • open-label treatment of 36 months Neramexane mesylate up to 75 mg per day

06

What researchers measure

Primary outcomes

  1. Long-term safety, Visual acuity

    Time frame: Baseline, week 4, month 3, 6, 9, 12, 18, 24, 30, 36 and follow-up

07

Study locations

1 site
  • University of Leicester, Leicester Royal Infirmary, Ophthalmology Group
    Leicester, LE2 7LX, United Kingdom
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 1, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00799942
First posted
Dec 1, 2008
Start date
May 2009
Last update
Jul 1, 2010

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Jun 2010. You cannot join it, but the record below documents what was studied.

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Studies of the drug tested here: Neramexane mesylate

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