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WithdrawnNCT00715065Updated Jan 9, 2013

fMRI in Blood Phobia Syncope

An observational study in Syncope, Blood Injury Phobia and Autonomic Dysfunction, sponsored by Vanderbilt University. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-01-09.

Sponsored by Vanderbilt University · Observational

Why this study was withdrawn
Could not get funding for fMRI studies at this time.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
0
Ages
18 Years to 30 Years
Sex
All
01

Study summary

We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain activation in response to seeing bloody or gory pictures that occur before the fainting occurs.

Read the detailed description

Another aim of the study is to determine whether or not differences in personality traits among people with blood phobia is associated with differences in BOLD signal responses during fMRI.

02

Conditions studied

  • Syncope
  • Blood Injury Phobia
  • Autonomic Dysfunction

Keywords

  • syncope
  • faint
  • blood
  • blood injury phobia
  • phobia
03

In context

Syncope

226 studies on the registry are indexed under Syncope; 45 are open to participants now.

Browse Syncope studies →

Lead sponsor

Vanderbilt University is the lead sponsor of 508 studies on the registry; 19 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 5 (71%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

  1. Patients with at least 1 prior syncopal episode in response to viewing blood
  2. Healthy subjects without a history of syncope

Inclusion criteria

  • 18-30 years of age
    1. History of at least one syncopal episode upon exposure to viewing blood (Case Group)
  • Negative urine pregnancy test on study day

Exclusion criteria

Exclusion Criteria:

  • Vasoactive medications (within 2 weeks of study day)
  • antihypertensives
  • beta blockers
  • vasoconstrictors
  • Psychotropic medications (within 4 weeks of study day)
  • History of psychostimulant or opiate use
  • History of alcohol, benzodiazepine or cannabis abuse or dependence
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
0 participants (actual)

Groups and cohorts

  • 2

    Healthy control subjects (who do not faint at the sight of blood)

    Procedure: fMRI Scan

  • 1

    People who faint at sight of blood

    Procedure: fMRI Scan

Interventions

  • ProcedurefMRI Scan

    Subjects will undergo a functional MRI scan of the head lasting \~45 minutes. They will be repeatedly shown video clips of blood, other disgusting things, or are neutral.

06

What researchers measure

Primary outcomes

  1. fMRI BOLD signal

    Time frame: Immediate

Secondary outcomes

  1. Blood Injection Symptoms Scale

    Time frame: Single visit

  2. Disgust Scale (Revised)

    Time frame: Single Visit

07

Study locations

1 site
  • Vanderbilt University Autonomic Dysfunction Center
    Nashville, Tennessee 37232-2195, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 9, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00715065
Lead sponsor
Vanderbilt University
Collaborators
National Institutes of Health (NIH)
Responsible party
Satish R. Raj (Assistant Professor, Vanderbilt University) — Principal investigator
First posted
Jul 15, 2008
Start date
Jun 2010
Primary completion
Jun 2010 (estimated)
Completion
Jun 2010 (estimated)
Last update
Jan 9, 2013

Study contacts

Satish R Raj, MD MSCI
principal investigator · Vanderbilt University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Jan 2013. You cannot join it, but the record below documents what was studied.

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