An interventional study of propofol and sevoflurane in Varicose Vein and Postoperative Pain, sponsored by The Cleveland Clinic. Terminated at 1 site in Austria. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-07-20.
Sponsored by The Cleveland Clinic · Not applicable, Interventional, and Prevention
The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.
Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning
253 studies on the registry are indexed under Varicose Veins; 35 are open to participants now.
This study's enrollment of 90 is below the median of 104 across 162 interventional studies indexed under Varicose Veins.
Browse Varicose Veins studies →The Cleveland Clinic is the lead sponsor of 818 studies on the registry; 118 are open to participants now.
Of its 89 completed or terminated interventional studies of FDA-regulated products, 72 (81%) have results posted.
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Exclusion Criteria:
Patients will receive propofol anesthesia during varicose vein stripping surgery.
Drug: propofol
Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.
Drug: sevoflurane
propofol anesthesia 3-5mg/kg
Also known as: Diprivan
sevoflurane anesthesia
The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.
Time frame: first post operative morning
To determine the average pain score for each group during the first four hours of recovery after surgery.
Time frame: 30 minute intervals for first 4 hours post operatively
Plan to share: No
This study is terminated, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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