An interventional study of Latanoprost, diclofenac and dorzolamide (eyedrops) and Diclofenac in Diabetic Retinopathy, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to participants aged 20 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-12-29.
Sponsored by University of Aarhus · Not applicable, Interventional, and Prevention
The purpose of this study is to determine if diabetic retinopathy can be treated with prostaglandin analogues, prostaglandin synthesis inhibitors or carbonic anhydrases inhibitors.
Disturbances in retinal perfusion is believed to be involved in the pathophysiology of diabetic retinopathy. These disturbances may be due to changes in the basal diameter of retinal arterioles and to disturbances in the autoregulation of the diameter of these vessels when the blood pressure and the retinal metabolism changes. In vitro studies have shown that prostaglandins and carbonic anhydrases inhibitors are involved in the tone regulation of retinal arterioles, but it is unknown whether this finding is relevant in clinical practice. This can be tested in vivo by an retinal vessel analyzer measuring the dynamics of the retinal vessel diameter changes.
815 studies on the registry are indexed under Retinal Diseases; 105 are open to participants now.
This study's enrollment of 87 is above the median of 60 across 500 interventional studies indexed under Retinal Diseases.
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Exclusion Criteria:
Medical intervention cross-over
Drug: Latanoprost, diclofenac and dorzolamide (eyedrops)
medical intervention
Drug: Diclofenac
dorzolamide eyedrops twice daily in one week
Drug: Dorzolamide
1 eyedrop twice daily in one week
Also known as: Xalatan, Voltaren ophtha, Trusopt
dicolfenac eyedrops twice daily i one eye
Also known as: Voltaren ophtha
dorzolamide eyedrops twice daily, in one eye for one week
Also known as: Trusopt eyedrops
Diameter of retinal blood vessels
Time frame: one year
Influence on retinal blood flow in diabetes
Time frame: one year
This study is completed, as verified in Dec 2010. You cannot join it, but the record below documents what was studied.
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University of Aarhus